MHC and HLA.txt

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Author:
nedi
ID:
227508
Filename:
MHC and HLA.txt
Updated:
2013-07-18 12:25:29
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  1. HLA-A, HLA-B, HLA-C.
    MHC I
  2. Binds TCR and CD8.
    MHC I
  3. Expressed on all nucleated cells. Not expressed on RBC.
    MHC I
  4. Antigen is loaded in RER with mostly intracellular peptides.
    MHC I
  5. Mediates viral immunity.
    MHC I
  6. Pairs with Beta2-microglobulin (aids in transport to cell surface).
    MHC I
  7. HLA-DR, HLA-DP, HLA-DQ.
    M HC II
  8. Binds TCR and CD4.
    M HC II
  9. Expressed only on antigen-presenting cells (APCs).
    M HC II
  10. Antigen is loaded following release of invariant chain in an acidified endosome.
    M HC II
  11. A3
    Hemochromatosis.
  12. B27
    • Psoriasis
    • Ankylosing spondylitis, Inflammatory PAIR.
    • bowel disease, Reiter's syndrome.
  13. DQ2/DQ8
    Celiac disease.
  14. DR2
    • Multiple sclerosis, hay fever, SLE,
    • Goodpasture's.
  15. DR3
    Diabetes mellitus type l, Graves' disease.
  16. DR4
    Rheumatoid arthritis, diabetes mellitus type l.
  17. DR5
    • Pernicious anemia -+ B12 deficiency,
    • Hashimoto's thyroiditis
  18. Psoriasis
    B27
  19. Ankylosing spondylitis
    B27
  20. Inflammatory bowel disease
    B27
  21. Reiter's syndrome.
    B27
  22. Multiple sclerosis
    DR2
  23. hay fever
    DR2
  24. SLE
    DR2
  25. Goodpasture's
    DR2
  26. Celiac disease.
    DQ2/DQ8
  27. Diabetes mellitus type l,
    DR3, DR4
  28. Graves
    B8, DR3
  29. RA
    DR4
  30. Pernicious Anemia
    DR5
  31. Hasimoto's
    DR5

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