IMmunoglobulins

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Author:
nedi
ID:
227512
Filename:
IMmunoglobulins
Updated:
2013-07-18 13:00:10
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  1. IgG
    Main antibody in secondary (delayed) response to an antigen. Most abundant isotype. Fixes complement,crosses the placenta (provides infants with passive immunity), opsonizes bacteria, neutralizesbacterial toxins and viruses.
  2. Main antibody in secondary (delayed) response to an antigen.
    IgG
  3. Most abundant isotype.
    IgG
  4. Fixes complement and crosses the placenta (provides infants with passive
    immunity),
    IgG
  5. opsonizes bacteria, neutralizes bacterial toxins and viruses.
    IgG
  6. IgA
    Prevents attachment of bacteria and viruses to mucous membranes; does not fix complement.Monomer (in circulation) or dimer (when secreted). Crosses epithelial cells by transcytosis. Foundin secretions (tears, saliva, mucus) and early breast milk (known as colostrum). Picks up secretorycomponent from epithelial cells before secretion.
  7. Prevents attachment of bacteria and viruses to mucous membranes; does
    not fix complement.
    IgA
  8. Monomer (in circulation) or dimer (when secreted).
    IgA
  9. Crosses epithelial cells by transcytosis.
    IgA
  10. Found in secretions (tears, saliva, mucus) and early breast milk (known as colostrum).
    IgA
  11. Picks up secretory component from epithelial cells before secretion.
    IgA
  12. IgM
    Produced in the Primary (immediate) response to an antigen. Fixes complement but does not cross theplacenta. Antigen receptor on the surface of B cells. Monomer on B cell or pentamer. Shape ofpentamer allows it to efficiently trap free antigens out of tissue while humoral response evolves.
  13. Produced in the Primary (immediate) response to an antigen.
    IgM
  14. Fixes complement but does not cross the placenta.
    IgM
  15. Antigen receptor on the surface of B cells.
    IgM
  16. Monomer on B cell or pentamer. Shape of pentamer allows it to efficiently trap free antigens out of tissue while humoral response evolves.
    IgM
  17. IgE
    Binds mast cells and basophils; cross-links when exposed to allergen, mediating immediate (type I)hypersensitivity through release of inflammatory mediators such as histamine. Mediates immunityto worms by activating eosinophils. Lowest concentration in serum.
  18. Binds mast cells and basophils;
    IgE
  19. cross-links when exposed to allergen, mediating immediate (type I)hypersensitivity through release of inflammatory mediators such as histamine.
    IgE
  20. Mediates immunity to worms by activating eosinophils.
    IgE
  21. Lowest concentration in serum.
    IgE

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