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IgG
Main antibody in secondary (delayed) response to an antigen. Most abundant isotype. Fixes complement,crosses the placenta (provides infants with passive immunity), opsonizes bacteria, neutralizesbacterial toxins and viruses.
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Main antibody in secondary (delayed) response to an antigen.
IgG
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Most abundant isotype.
IgG
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Fixes complement and crosses the placenta (provides infants with passive
immunity),
IgG
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opsonizes bacteria, neutralizes bacterial toxins and viruses.
IgG
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IgA
Prevents attachment of bacteria and viruses to mucous membranes; does not fix complement.Monomer (in circulation) or dimer (when secreted). Crosses epithelial cells by transcytosis. Foundin secretions (tears, saliva, mucus) and early breast milk (known as colostrum). Picks up secretorycomponent from epithelial cells before secretion.
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Prevents attachment of bacteria and viruses to mucous membranes; does
not fix complement.
IgA
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Monomer (in circulation) or dimer (when secreted).
IgA
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Crosses epithelial cells by transcytosis.
IgA
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Found in secretions (tears, saliva, mucus) and early breast milk (known as colostrum).
IgA
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Picks up secretory component from epithelial cells before secretion.
IgA
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IgM
Produced in the Primary (immediate) response to an antigen. Fixes complement but does not cross theplacenta. Antigen receptor on the surface of B cells. Monomer on B cell or pentamer. Shape ofpentamer allows it to efficiently trap free antigens out of tissue while humoral response evolves.
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Produced in the Primary (immediate) response to an antigen.
IgM
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Fixes complement but does not cross the placenta.
IgM
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Antigen receptor on the surface of B cells.
IgM
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Monomer on B cell or pentamer. Shape of pentamer allows it to efficiently trap free antigens out of tissue while humoral response evolves.
IgM
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IgE
Binds mast cells and basophils; cross-links when exposed to allergen, mediating immediate (type I)hypersensitivity through release of inflammatory mediators such as histamine. Mediates immunityto worms by activating eosinophils. Lowest concentration in serum.
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Binds mast cells and basophils;
IgE
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cross-links when exposed to allergen, mediating immediate (type I)hypersensitivity through release of inflammatory mediators such as histamine.
IgE
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Mediates immunity to worms by activating eosinophils.
IgE
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Lowest concentration in serum.
IgE
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