Cytokines & Complement

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Author:
nedi
ID:
227518
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Cytokines & Complement
Updated:
2013-07-18 13:28:42
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  1. Classic pathway-
    IgG or IgM mediated.
  2. Alternative pathway-.
    microbe surface molecules
  3. Lectin pathway-.
    mannose or other sugars on microbe surface
  4. C3b-
    opsonization.
  5. C3a, C5a-
    anaphylaxis.
  6. C5a-
    neutrophil chemotaxis.
  7. C5b-9-
    cytolysis by MAC.
  8. C1 esterase inhibitor deficiency
    hereditary angioedema. ACE inhibitors are contraindicated.
  9. C3 deficiency
    • severe, recurrent pyogenic sinus and respiratory tract infections; increases
    • susceptibility to type III hypersensitivity reactions.
  10. C5-C9 deficiencies
    leads to recurrent Neisseria bacteremia.
  11. DAF (GPI anchored enzyme) deficiency
    leads to complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria (PNH).
  12. "Hot T-Bone stEAk":IL-l: fever (hot).IL-2: stimulates T cells.IL-3: stimulates Bone marrow.IL-4: stimulates IgE production.IL-5: stimulates IgA production.
    .
  13. SECRETED BY MACROPHAGES
    IL-1, IL-6, IL-8, IL-12, TNF-a
  14. SECRETED BY ALL T CELLS
    IL-2, IL-3
  15. FROM Th1 CELLS
    lnterferon-gamma
  16. FROM Th2 CELLS
    IL-5, IL-10
  17. IL-1
    An endogenous pyrogen. Causes fever,acute inflammation. Activates endotheliumto express adhesion molecules; induceschemokine secretion to recruit leukocytes.
  18. IL-6
    An endogenous pyrogen. Also secreted by Th2cells. Causes fever and stimulates productionof acute-phase proteins.
  19. IL-8
    Major chemotactic factor for neutrophils.
  20. IL-12
    Induces differentiation of T cells into Th1 cells.Activates NK cells. Also secreted by B cells.
  21. TN F-a
    Mediates septic shock. Activates endothelium.Causes leukocyte recruitment, vascular leak.
  22. IL-2
    Stimulates growth of helper, cytotoxic, and regulatory T cells.
  23. IL-3
    Supports the growth and differentiation of bonemarrow stem cells. Functions like GM-CSF.
  24. lnterferon-y
    Activates macrophages and T h1 cells.Suppresses Th2 cells. Has antiviral andantitumor properties.
  25. IL-4
    Induces differentiation into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG.
  26. IL-5
    Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates the growth and differentiation of eosinophils.
  27. IL-10
    Modulates inflammatory response. Inhibits actions of activated T cells and Th1 . Also secreted by regulatory T cells.
  28. TGF- B
    has similar actions to IL-10, because it isinvolved in inhibiting inflammation.
  29. a- and B interferons
    inhibit viral protein synthesis.
  30. y-interferons
    increase MHC I and II expression anda ntigen presentation in all cells.

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