Therapeutic Intranasal Drug Delivery

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  1. Intranasal Midazolam indication?
    For treatment of persistent seizure activity.
  2. Dose of Midazolam intranasally?
    • Children:
    • Total kg wt x 0.2 mg = dose

    • Adult:
    • 50 kg > = 10mg
  3. What is the next dosage after the first administration of Midazolam intranasally?
    If seizure persist 5 minutes after treating, consider repeating 1/2 dose of Midazolam either intranasally, intramuscularly, or intravenously.
  4. How does Midazolam absorbed intranasally?
    Rapidly absorbed through the lining of the nose into the bloodstream, it travels directly to the brain where it acts on the GABA mechanism to inhibit the seizure activity.
  5. What are the drawbacks of Intranasal Midazolam?
    • -Mild nasal irritation because of the acidity.
    • -The capacity of the nose to handle a liquid is 1/2 ml - no more. Therefore, a lot of the fluid will end up being swallowed, which make it difficult to determine the optimal dose for a patient.
    • -Half-life of midazolam is short. A possible second dose may be needed.
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Therapeutic Intranasal Drug Delivery
2013-07-22 04:31:26
Vesed Intranasal

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