18 - Immunologic Disorders

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18 - Immunologic Disorders
2010-06-09 15:58:23
Immunologic Disorders

18 - Immunologic Disorders
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  1. What are Type I Hypersensitivities?
    • IgE mediated
    • Occurs when antigen makes contact with body, and binds to receptors on mast cells and basophiles
    • Characterized by immediate reaction of individual
    • Inherited
    • Can be local anaphylaxis - one spot, or generalized anaphylaxis - whole body
  2. What is anaphylaxis?
    Name given for IgE mediated allergic reactions
  3. Types of localized anaphylaxis:
    • Hives - wheal and flare rash
    • Hay fever - teary eyes, sneezing, runny nose
    • Asthma - inflamed respiratory tract
  4. What is generalized anaphylaxis?
    • Antigen enters blood stream and becomes wide spread
    • May induce shock
  5. What is immunotherapy/densensitization/hyposensitization?
    Technique used to modify immune system by injecting individual with extremely diluted suspension of allergen
  6. What are Type IV Hypersensitivities?
    • Delayed hypersensitivities caused by cell mediated immunity.
    • T-Cells are responsible
    • Body slowly develops a response to antigen
    • Responsible for contact dermatitis, rejection of tissue grafts, some autoimmune diseases.
    • TB test
  7. How do T-Cells cause Type IV Hypersensitivities?
    T-Cells release cytokines, which initiate inflammation, which attracts macrophages
  8. Examples of contact hypersensitivities - type IV?
    • Poison Ivy/Oak
    • Nickel in metal jewelry
    • Chromium salts in leather
    • Latex products
  9. What is an auto-immune disease?
    A disease that causes the body to attacks its own tissues