Present with a rapidly enlarging symptomatic mass, most usually nodal enlargement in the neck or abdomen.
Systemic "B" symptoms (ie, fever, weight loss, drenching night sweats) are observed in approximately 30 percent of patients
Serum LDH is elevated in over one-half
60 percent of patients will present with advanced stage DLBCL (usually stage III or IV disease) while 40 percent have more localized disease, usually defined as that which can be contained within one irradiation field
Bone marrow is involved in up to 30 percent of cases
Extranodal extramedullary disease occurs in up to 40 percent of cases
In U.S., about 50% EBV infection.
May present as abdominal mass.
Most rapidly growing human tumor.
Typical chromosome abnormality: c-myc oncogene linked to one of the immunoglobulin genes.
Classical feature for hodkin's lymphoma
what need to make dxn for hodgkin's disease
Hodgkin's sign and symptom
Lymph node enlargement, usually
cervical or mediastinal.
Systemic “B” symptoms common.
–relapsing, high-grade fever that
can reach 105-106°F, periodicity of 7-10 days. Fever spikes abrupt in onset and