Direct Factor Xa inhibitors

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Author:
merazar15
ID:
228595
Filename:
Direct Factor Xa inhibitors
Updated:
2013-07-30 09:41:29
Tags:
pharm direct Factor Xa inhibitors
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Description:
pharm- direct factor Xa inhibitors
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  1. direct factor Xa inhibitor drugs:
    Rivaroxaban
  2. MOA:
    directly inhibit the conversion of prothrombin to thrombin without using antithrombinIII as an intermediary
  3. indication:
    • Postsurgical VTE prophylaxis ·        
    • As an alternative to heparins in patients with severe HIT
  4. Dose for Rivaroxaban:
    • Initial: 15-20 mg po daily for 3 weeks
    • on exam (20 mg)
  5. CI:
    • active bleeding
    • Pregnancy
    • pts at increased risk of bleeding
  6. SE:
    bleeding
  7. DI:
    • Metabolism is via CYP450 3A4 enzymes
    • It is a substate of P-glycoprotein (Pgp)
    • There are no monitoring requirements

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