Salicylates

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Author:
merazar15
ID:
228603
Filename:
Salicylates
Updated:
2013-07-30 11:00:32
Tags:
Salicylates
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Description:
pharm-salicylates
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  1. drugs:
    • Acetylsalicylic acid (Aspirin (ASA))
    • Ecotrin
    • Bayer
  2. MOA:
    Inhibits COX, decreases Thromboxane A2 (TXA2) which increases platelet aggregation
  3. indication:
    • Moderate pain relief
    • Tx of MI
    • 1st line agent in MI prevention·        
    • Prevent Stroke
    • Prevent TIA
  4. dose of aspirin:
    81 mg to 325 mg once daily
  5. why is ASA not for children?
    • Causes Reye's syndrome (common in 5-11 yrs of age)
    • Fatal encephalopathy in children when using ASA during viral infection
  6. SE:
    • GI (frequent & significant) enteric coated or buffered helps
    • bleeding (stop ASA 7 days before surgery)
    • Tinnitus (high doses)
  7. salicylate poisoning in adults. what do you do?
    • Plasma salicylate concentration·(Repeat every two hours until it is declining)
    • ABG (Repeat every two hours until acid-base status stable or improving)
    • Treatment ·        
    •     Oxygen·        
    •    Activated charcoal (first dose: 1 g/kg orally up to 50 g) ·        
    •    IV dextrose 50 g as 100 mL of 50 percent dextrose·        
    •    Sodium bicarbonate, 1 to 2 mEq/kg (maximum 100 mEq) IV push
    •    Hemodialysis·        
    •    Call poison control

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