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- Acetylsalicylic acid (Aspirin (ASA))
Inhibits COX, decreases Thromboxane A2 (TXA2) which increases platelet aggregation
- Moderate pain relief
- Tx of MI
- 1st line agent in MI prevention·
- Prevent Stroke
- Prevent TIA
dose of aspirin:
81 mg to 325 mg once daily
why is ASA not for children?
- Causes Reye's syndrome (common in 5-11 yrs of age)
- Fatal encephalopathy in children when using ASA during viral infection
- GI (frequent & significant) enteric coated or buffered helps
- bleeding (stop ASA 7 days before surgery)
- Tinnitus (high doses)
salicylate poisoning in adults. what do you do?
- Plasma salicylate concentration·(Repeat every two hours until it is declining)
- ABG (Repeat every two hours until acid-base status stable or improving)
- Treatment ·
- Activated charcoal (first dose: 1 g/kg orally up to 50 g) ·
- IV dextrose 50 g as 100 mL of 50 percent dextrose·
- Sodium bicarbonate, 1 to 2 mEq/kg (maximum 100 mEq) IV push
- Call poison control
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