erythropoietins

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Author:
merazar15
ID:
228618
Filename:
erythropoietins
Updated:
2013-07-30 14:34:16
Tags:
erythropoietins
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Description:
pharm
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  1. drugs:
    • Epoetin
    • Darepoetin
  2. kinetics for
    Epoetin alpha:
    Darbepoetin alpha:
    • Epoetin: elimination half-life is 4-8 hrs
    • Darbepoetin: prolonged elim half-life; approx. 24 hrs, given IV or SC 1x q 4 wks
  3. indication:
    anemia
  4. dosing titrate for chemotherapy- only initiate treatment if hemoglobin is:
    <10 g/dL
  5. what do you have to monitor when using erythropoietins?
    Results of any dose adjustments made in response to this would not be seen for:
    • Hematocrit!
    • 2-6 wks
  6. Do  not increase the dose more frequently than:
    once q 4 wks
  7. SE:
    • iron deficiency
    • thrombosis
    • HTN!!
    • seizures
  8. CI:
    uncontrollable HTN
  9. what is the target goal for hemoglobin?
    ≤11 g/dL

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