Colony-stimulating factors:

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Author:
merazar15
ID:
228619
Filename:
Colony-stimulating factors:
Updated:
2013-07-30 14:40:17
Tags:
Colony stimulating factors
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Description:
Pharm
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  1. description of drugs?
    trying to increase the amount of neutrophils. If they are low, you can't fight infections.
  2. Drugs:
    • Granulocyte Colony-Stimulating Factor (G-CSF)
    • Filgrastim
    • Pegfilgrastim

    • Granulocyte-Monocyte Colony-Stimulating Factor (GM-CSF) 
    • Sargramostim
  3. kinetics for Pegfilgrastim:
    • extended elimination half-life: 40 hrs!
    • Produced by the addition of a polyethylene glycol (PEG) to filgrastim
    • Not as readily cleared by the kidneys Due to large size
  4. indications:
    • Adjunct to myelosuppressive chemotherapy
    • Severe chronic neutropenia
    • Prevention and treatment of neutropenia in HIV infection
  5. SE:
    • Bone loss
    • Joint pain
    • Sickle cell crises
    • Renal dysfunction
    • Acute respiratory distress
    • Splenomegaly or splenic rupture

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