For these kinds of drugs, treatment consists of several kinds to prevent resistance from single type. Prophylactic treatment is recommended for asymptomatic patients that develop skin test positivity and for your (<4 years) or immunocompromised patients that are exposed to an infectious case of tuberculosis.
Anti cancer drugs are much more toxic to tissues with ___1__ growth fraction than to tissues with ___2__ growth fraction.
Solid tumors have a low growth fraction and therefore tend to respond ____1____ to chemotherapy. In contrast, disseminated cancers have a high growth fraction and generally respond ____2____ to chemotherapy.
These agents are generally more effective against slow-growing tumors than other classes of antineoplastics.
What are the indications for taking Methotrexate?
Cancers: pediatric acute lymphocytic leukemia, osteogenic sarcoma, Burkitts lymphoma, non-Hodgkin's lymphoma, head and neck sarcomas, choriocarcinoma
Severe psoriasis (in low doses)
Unlike most other anticancer drugs, _________, exerts minimal toxicity to bone marrow (non-immunosuppressive). Nausea and vomiting are usually mild.
*this is an excellent choice for combination therapy
This is the drug of choice for estrogen receptor-positive breast cancer in postmenopausal women.
This is the drug of choice for advanced carcinoma of the prostate.
This drug is one of the most effective agents against solid tumors.
What are the effects of Aspirin?
Anti-inflammatory (heat, swelling, pain)
Antipyretic (heat / fever)
What are the uses of Aspirin?
Relieve fever, pain, inflammation (arthritis), Decrease TIA
For Heart conditions
Decrease incidence of Colon Cancer
What are contraindications of Aspirin?
Peptic ulcer disease
What are the effects of Ibuprofen / Naproxen?
*equivalent to Aspirin but more analgesic effect than aspirin / acetaminophen
Ketorolac (Toradol) is indicated for?
Short-term pain management
What are the effects of Acetaminophen (Tylenol)?
What are the uses of Acetaminophen (Tylenol)?
Mild to Moderate pain and fever
Preferred over Aspirin due to Reye's Syndrome
What are adverse effects of Acetaminophen (Tylenol)?
Rash / drug fever due to allergic reaction
Overdose may cause hepatic necrosis (liver death) leading to coma and death