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  1. Typical Anti-psychotics (12)
    • Thioridazine (Mellaril)
    • Chlorpromazine (Thorazine)
    • Mesoridazine (Serentil)
    • Molindone (Moban)
    • Perphenazine (Trilafon)
    • Loxapine (Loxitane, Daxolin)
    • Trifluoperazine (Stelazine)
    • Thiothixene (Navane)
    • Haloperidole (Haldol)
    • Fluphenazine (Prolixin)
    • Pimozide (Orap)
  2. Atypical (6)
    • Aripiprazole (Abilify)
    • Clozapine (Clozaril)
    • Risperidone (Risperdal)
    • Olanzapine (Zyprexa)
    • Quetiapine (Seroquel)
    • Ziprasidone (Geodon)
  3. Typical anti-psychotics and risperidone strongly block which receptors?
    D2 receptors
  4. Blockade of dopamine in cortical and limbic produces?
    Reduction in psychotic S/S
  5. Blockade of dopamine in basal ganglia produces?
    Extrapyramidal S/S
  6. Which antipsychotic is effective in treating refractory psychotic S/S?
    Clozapine (Clozaril)
  7. Which anti-psychotic is approved for use in acute bipolar mania and for maintenance tx of bipolar disorder?
    Olanzapine (Zyprexa)
  8. Which 2 anti-psychotics are approved for agitation in schizophrenia?
    • Olanzapine (Zyprexa)
    • Ziprasidone (Geodon)
  9. Which atypical anti-psychotics are approved for bipolar disorder?
    • Olanzapine (Zyprexa)
    • Risperidone (Risperdal)
    • Ziprasidone (Geodon)
    • Aripiprazole (Abilify)
  10. What neurological SE must be monitored for when taking antipsychotics?
    • Akathisia (restlessness)
    • Neuroleptic malignant syndrome (NMS)
    • Extrapyramidal S/S (EPS)
    • Seizure activity
  11. What must be monitored in pt taking clozapine?
    • WBC counts
    • B/c of agranulocytosis
  12. What are common SE of low potency antipsychotics? (4)
    • Anti-cholinergic SE (dry mouth, constipation, urinary retention, blurred vision)
    • Reduced seizure threshold
    • Cardiac SE (QT prolongation - torsade de pointes)
    • Orthostatic hypotension
  13. Which atypical anti-psychotic reduces seizure threshold?
  14. Which anti-psychotics are associated with orthostatic hypotension?
    • Low-potency agents
    • Risperidone (Risperdal)
  15. Which anti-psychotic is associated with agranulocytosis?
    Clozapine (Clozaril)
  16. Which anti-psychotics are associated with QT prolongation?
    • Low-potency agents
    • Ziprasidone (Geodon)
  17. Which anti-psychotics are associated with high rates of weight gain, dyslipidemia, and adult-onset of diabetes? (2)
    • Olanzapine (Zyprexa)
    • Clozapine (Clozaril)
  18. Which anti-psychotic can cause pigmentary retinopathy and increased prolactin levels at high does?
    Thioridazine (Mellaril)
  19. Which anti-psychotic increases risk of developing cataracts?
    Quetiapine (Seroquel)
  20. Which class of anti-psychotics are considered the 1st line tx for psychotic disorders?
    Atypical anti-psychotics
  21. What is the MOA of atypical anti-psychotics?
    Dopamine and serotonin blockade of receptors
  22. Which are the traditional high-potency anti-psychotics?
    • Haloperidol (Haldol)
    • Droperidol (Inapsine)
    • Fluphenzaine (Prolixin)
    • Thiothixene (Navane)
  23. Which are the traditional medium-potency anti-psychotics?
    • Trifluoperazine (Stelazine)
    • Perphenazine (Trilafon)
  24. Which are the traditional low-potency anti-psychotics?
    • Thioridazine (Mellaril)
    • Chlorpromazine (Throazine)
  25. What are common SE of high potency anti-psychotics? (3)
    • Tardive dyskinesia
    • anti-cholinergic SE
    • Neuroleptic malignant syndrome
  26. What is neuroleptic malignant syndrome?
    • Uncommon complication of antipsychotic meds that starts w/in days of usage
    • High fever, muscle rigidity, increased BP and HR
    • Tx: stop drug and administer dantrolene
  27. What is tardive dyskinesia?
    • Complication of anti-psychoitc use begins several months after therapy
    • Characterized by repetitive facial movements
    • Tx: stop drug, may be irreversible
Card Set:
2013-08-06 22:49:49
Anti psychotics

Anti-psychotic drugs
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