Naplex 12

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Author:
bblapham
ID:
229907
Filename:
Naplex 12
Updated:
2013-08-13 17:11:08
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HIV cephalosporins
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Description:
HIV and cephalosporins
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  1. Cefadroxil
    1st generation PO
  2. Kefzol
    • Cefazolin IV
    • 1st generation
  3. Keflex
    • Cephalexin PO
    • 1st generation
  4. Cefaclor
    2nd generation PO
  5. Cefotetan
    2nd generation IV
  6. Mefoxin
    • Cefoxitin
    • 2nd generation IV
  7. Cefprozil
    2nd generation PO
  8. Ceftin
    • Cefuroxime
    • 2nd generation PO/IV
  9. Zinacef
    • Cefuroxime
    • 2nd generation PO/IV
  10. Omnicef
    • Cefdinir
    • PO 3rd generation
  11. Spectracef
    • Cefditoren PO
    • 3rd generation
  12. Suprax
    • Cefixime
    • 3rd generation PO
  13. Claforan
    • Cefotaxime
    • 3rd generation IV/IM
  14. Cefpodoxime
    • 3rd generation
    • PO
  15. Fortaz
    • Ceftazidime
    • 3rd generation IV
  16. Tazicef
    • Ceftazidime
    • 3rd generation IV
  17. Cedax
    • Ceftibuten
    • 3rd generation PO
  18. Rocephin
    • Ceftriaxone
    • 3rd generation IV/IM
  19. Maxipime
    • Cefepime
    • 4th generation IV
  20. Teflaro
    • Ceftaroline
    • 5th generation IV
  21. NRTIs
    • Class toxicities: lactic acidosis, severe hepatomegaly with steatosis
    • All require renal dosing except abacavir
  22. NRTIs to NOT use together
    • 1. lamivudine and emtricitabine
    • 2. zidovudine and stavudine
    • 3. didanosine and stavudine
    • 4. didanosine and tenfovir
  23. D drugs
    • Cause pancreatitis, peripheral neuropathy and lactic acidosis
    • Didanosine, stavudine, and zalcitabine
  24. Retrovir
    • Zidovudine
    • Bone marrow suppression, GI intolerance
    • Available IV
  25. Epivir
    • Lamivudine
    • Minimal toxicity
  26. Ziagen
    • Abacavir
    • Fatal hypersensitivity reactions
  27. Videx
    • Didanosine
    • Empty stomach
    • Pancreatitis, peripheral neuropathy
  28. Zerit
    • Stavudine
    • Pancreatitis
    • Peripheral neuropathy
  29. Hivid
    • Zalcitabine
    • Pancreatits
    • Peripheral neuropathy
  30. Viread
    • Tenofovir
    • Renal insufficiency, Fanconi syndrome
  31. Emtriva
    • Emtricitabine
    • Minimal toxicity
  32. Combivir
    Zidovudine and lamivudine
  33. Trizivir
    Zidovudine, lamivudine, and abacavir
  34. Truvada
    Tenofovir, emtricitabine
  35. Epzicom
    Lamivudine and abacavir
  36. Cephs available PO (10)
    Cephalexin, cephadroxil, cefaclor, cefprozil, cefuroxime, cefdinir, cefditoren, cefixime, cefpodoxime, ceftibuten
  37. NNRTIs
    • Class toxicities: rash and hepatotox
    • All dosed for hepatic impairment
    • All effected by food (except efavirenz)
  38. Sustiva
    • Efavirenz
    • Take on empty stomach
    • CNS side effects, false cannabinoid test
  39. Viramune
    • Nevirapine
    • Autoinducer
    • Rashm hepatitis
  40. Rescriptor
    • Delavirdine
    • Rash, increased LFTs
  41. PIs
    • All should be dosed for hepatic impairment
    • All should be taken with food (except amprenavir and indinavir)
    • Toxicities: lipodystrophy,
    • hyperglycemia, hyperlipidemia, hypertriglyceridemia, bleeding in hemophiliace,
    • osteonecrosis & avascular neocrosis of the hips, osteopenia &
    • osteoporosis
  42. Which PIs required refrigeration?
    Lopinavir/ritonavir, ritonavir, and saquinavir
  43. Kaletra
    • Lopinavir and ritonavir
    • SE: GI intolerance, hyperglycemia
    • Stable for 2 months at room temp
  44. Reyataz
    • Atazanavir
    • INcreased hyperbilirubinemia, prolonged PR interval
  45. Lexiva
    • Fosamprenavir
    • SE: rash
    • Sulfonamide
  46. Agenerase
    • Amprenavir
    • Rash
    • Avoid high fat meal
  47. Invirase
    • Saquinavir hard gel cap
    • GI intolerance
    • Room temperature
  48. Fortovase
    • Saquinavir soft gel cap
    • SE: GI intolerance
    • Stable for 3 months at room temperature
  49. Viracept
    • Nelfinavir
    • Diarrhea, take after eating
  50. Norvir
    • Ritonavir
    • Gi interolance
    • Stable for 1 montha at room temperautre
  51. Crixivan
    • Indinavir
    • Nephrolithiasis
    • Empty stomach
  52. Fuzeon
    • Enfuvirtide 90 mcg SC BID
    • injection site reactions
    • Fusion inhibitor
    • Keep in fridge
  53. Selzentry
    • Maraviroc 300 mg BID 
    • CCR5 inhibitor
    • hepatotoxicity, rash
    • Only work with CCR5 tropic disease
  54. Isentress
    • Raltegravir 400 mg BID
    • Integrase inhibitor
  55. HIV drugs available as suspension
    Nevirapine
  56. HIV drugs available as syrup and oral solution
    Epivir, Ziagen, Videx, Kaletra, Agenerase, Viracept, and Norvir
  57. PCP treatment
    • Treat when CD+ cells fall below 200
    • Bactrim DS po QD
  58. MAC
    • Treat when CD4 cells fall below 50
    • Azithromycin 1200 mg po Q week
  59. CMV
    • Ganciclovir (Cytovene, Vitrasert)
    • Use: treatment of CMV retinitis in immunocompromised individuals, including patients with AIDS
    • ii)    CI: ANC <500/mm3 or PLT 25,000/mm3
    • iii)  Dosage forms:
    • (1)  Capsule (Cytovene)
    • (2)  Implant, intravitreal (Vitrasert)- 4.5 mg released gradually over 5-8 months
  60. Truvada
    Emtricitabine 200 tenfovir 300 1 daily
  61. Combivir
    Lamivudine 150 and zidovudine 300 1 BID
  62. Epzicom
    Abacavir 600 and lamidvudine 300 1 daily
  63. Trizivir
    Abacavir 300 lamivudine 150 zidovudine 300 1 BID
  64. Atripla
    Emtricitabine 200 tenofovir 300 efavirenz 600 1 daily on empty stomach
  65. Complera
    Emtricitabine 200 tenofovir 300 rilpivirine 25 1 daily with food
  66. Stribild
    Emtricitabine 200 tenofovir 300 elvitegravir 150 and cobicistat 150 1 daily with food
  67. Recommended Regimens (5)
    • Atripla (emtricitabine, tenofovir, efavirenz)
    • Truvada (emtricitabine, tenofovir) + atazanavir/ritonavir
    • Truvada + darunavir/ritonavir
    • Raltegravir + truvada
    • Lopinavir/ritonavir + ziduvudine and lamivudine (combivir)
  68. Eopgen
    Epoetin alfa
  69. Procrit
    Epoetin Alfa
  70. Aransep
    • Darbopoetin
    • Less frequent dosing than epoetin alfa

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