Card Set Information
Inflammation results in ...
permanent destruction of tissue
or complete healing (by removing noxious agents and repair dmg tissue)
released by a variety of physical and
platelet aggregation, vasodilation, vascular permeability and increase pain sensitivity to other mediators
involved in immediate hypersensitivity
damaged host tissue such as collagen, elastin, mucopolysaccharide and basement membrane.
which tissue mediator dmg tissue?
which protein triggering mast cell degranulation, which in turn leads to increased vascular permeability
stimulate the function of T and B cells.
Monocyte chemoattractive protein-1
promotes accumulation of monocyte.
antivival and macrophage activation
skin reactive factor
mimics a delayed allergic rxn
reactive metabolites of oxygen, INF-a, IL-1 and TNF-a
IL, MCP-1, GM-CSF, INF-a, skin reactive factor
mast cell product
PGs derived from
COX1 vs COX2
COX1 can be block by aspirin is a constitutive enzyme and functions in regulating renal blood flow and fluid and electrolyte transport.
COX 2 is inducible enxyme that fxn in inflammation
Maintain the integrity of the mucosa
regulation of renal blood flow, fluid and electrolyte transport.
maintain mucosa integrity in the stomach.
enhances chemotactic responses in human neutrophils, monocytes, and eosinophils
LTC4 and LTD4
bronchial constriction and mucosal edema
C3a and C5a (anaphylatoxin)
bacterial lysis, phagocytosis, chemotaxis, vasodilation and increase permeability.
blood test for C3,4 indicate
recurrent bacterial endotoxin
What produce C1
what produce C3
plays a regulatory and a proinflammatory
role in various inflammatory conditions
inhibition of iNOS has proinflamatory effect
which enzyme aid in production of brady kinin
which drug is the exception to NSAID (doesn't have antiflamatory fxn)? why?
acetaminophen only analgesic and antipyretic but not antinflamatory fxn
Which COX-2 inhibitor is the only safe drug on the market?
Aspirin - MofA
uniquely inactivates COX by irreversibly acetylating the enzyme.