Mood Stabilizers

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Most common mood stabilizers (4)?
- Lithium
- Valproate
- Carbamazepine
- Lamotrigine
Uses of Lithium (4)
- Acute mania
- Long-term maintenance in bipolar disorder
- Augmentation of antidepressant medications
- Impuse dyscontrol
- Decrease suicide
Uses of valproate (4)
- Acute mania
- Rapid-cycling bipolar disorder
- Mixed features bipolar disorder
- Impuse dyscontrol
Uses of carbamazepine (4)
- Acute mania
- Rapid-cycling bipolar disorder
- Mixed features bipolar disorder
- Impulse dyscontrol
Lamotrigine (2)
- Long-term maintenance in bipolar disorder
- Mixed features bipolar disorder
Lithium targets which NTs? (3)
- Norepinephrine
- Serotonin
- GABA
How is lithium cleared?

Renally
What should be monitored regularly while on Lithium (2)
- Thyroid-stimulating hormone
- Creatinine
What is the MOA of valproate? (3)
- Increases GABA synthesis
- Decreases GABA breakdown
- Enhances its postsynaptic efficacy
Which is more effective for rapid-cycling and mixed variants of bipolar disorder - valproate or lithium?

Valproate
Where is valproate metabolized?

Liver
What are serious SE of valproate? (3)
- Fatal hepatotoxicity
- Fulminant pancreatitis
- Agranulocytosis
Is lamotrigine approved for acute treatment of mania?

No
Is lamotrigine more effective in treating the depressive or manic phase of bipolar I disorder?

Despressive
What allergic skin rash develops with lamotrigine?

Stevens-Johnson's syndrome
Serious SE of carbamazepine (3)
- Agranulocytosis
- Pancytopenia
- Aplastic anemia
Gabapentin is a useful adjunct therapy for?

Anxiolysis in bipolar disorder
Name atypical antipsychotics approved for mood component of bipolar disorder (5)
- Olanzapine
- Quetiapine
- Risperidone
- Ziprasidone
- Aripiprazole

Author

sini

229918

Card Set

Mood Stabilizers

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Mood Stabilizers

Updated

2013-08-13T22:05:18Z

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