Anxiolytics

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Author:
sini
ID:
229925
Filename:
Anxiolytics
Updated:
2013-08-13 19:46:45
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Anxiolytics
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Anxiolytics
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  1. List indications of benzodiazepines (5)
    • Anxiety disorders
    • -GAD
    • -Panic disorder

    • Mood disorders
    • -anxiety with depression
    • -insomnia with depression
    • -agitation with acute mania
    • -mood stabilizer with bipolar

    Adjustment disorders

    Sleep disorders (insomnia)

    • Miscellaneous
    • -akathisia
    • -agitation with psychosis
    • -catatonia (esp lorazepam)
    • -EtOH w/drawal
  2. What is the MOA of benzos?
    GABA receptor agonists
  3. Which benzos are used for panic disorder? (2) and why?
    • Alpraolam
    • Clonazepam
    • High-potency
  4. Which benzos are used for insomnia (3) and why?
    • Flurazepam
    • Triazolam
    • Diazepam
    • Fast-onset and short 1/2 life
  5. Which benzos are less likely to accumulate toxic levels with liver disease (3) and why?
    • Lorazepam
    • Oxazepam
    • Temazepam
    • Do not require oxidation in the liver
  6. Which drug is a favored alternative to tx anxiety in pts with history of substance abuse?
    Buspirone
  7. What is the MOA of buspirone? (2) Is it fast-acting?
    • 5HT receptor agnoist
    • some D2 antagonist
    • No - takes weeks to become effective
  8. Does Buspirone have any GABA affinity?
    No.
  9. Is Buspirone a sedative?
    No

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