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systemic reactions from LA
- toxicity from both LA and Vaso
LA toxicity if given in excessive doses, intravascular manifests as...
CNS toxicity then CVS
What is the most potent LA and affects CVS?
what is the least potent LA?
atricane has a ester group
What happens when the LA has high concentration in blood but tissue isnt numb?
LA was injected in blood vessel rather than tissue space.
what happens upon increase in CBF?
Brain gets more blood and more drugs
What are signs of brain toxicity?
- patient is sweaty and experiences and adrenaline rush.
- worst case: seizure or unconscious coma and die
Facilitatory impulses, and then both are gone
severe CNS toxicity
- respiratory depression
low CNS toxicity
LETAL LA toxicity
- respiratory arrest
- CVS collapse
which drugs have higher max doses?
proliocane and articane
when administereing LA to children go by....
Why is articane not used on children?
b/c it has higher concentration of solution.
No Brainer Mthod of LA dosage determination:
0.5 cartridge per 10 Lb
Main causes of LA toxcity (esp in children)
- intravascular injection
- inject too fast
- injected too much
What would you like to do?
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