B-cell neoplasms_Fellowship

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Author:
dowong
ID:
229949
Filename:
B-cell neoplasms_Fellowship
Updated:
2013-08-13 23:43:21
Tags:
cell neoplasms Fellowship
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Description:
B-cell neoplasms_Fellowship
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  1. What are three features help make a diagnosis of marginal zone lymphoma?
    • 1) CD43 aberrant expression (gut and nodal/BM, NOT splenic)
    • 2) light chain restriction in lymphocytes +/- plasma cells (if present)
    • 3) sheets of monocytoid B cells outside follicles (outside CD21 staining)
  2. What is the characteristic staining pattern for LR-HD? What are the clinical factors? What other malignancy can look like this?
    Nodules of large CD20 negative cells rimmed by CD20- T-cells, which are surrounded by a background of CD20+ B-cells (rarely diffuse); predominantly male; NLPHD
  3. What marker is useful for the T-cells surrounding large B-cells in NLPHD?
    CD57
  4. What NS HD variant has prominent aggregates of R-S cells?
    Syncytial variant
  5. Lymphomatoid Granulomatosis findings?
    • 1) EBV immunoblasts are CD20+
    • 2) Variable CD30+ but CD15-
    • 3) Background CD4>CD8 T-cells

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