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What are three features help make a diagnosis of marginal zone lymphoma?
- 1) CD43 aberrant expression (gut and nodal/BM, NOT splenic)
- 2) light chain restriction in lymphocytes +/- plasma cells (if present)
- 3) sheets of monocytoid B cells outside follicles (outside CD21 staining)
What is the characteristic staining pattern for LR-HD? What are the clinical factors? What other malignancy can look like this?
Nodules of large CD20 negative cells rimmed by CD20- T-cells, which are surrounded by a background of CD20+ B-cells (rarely diffuse); predominantly male; NLPHD
What marker is useful for the T-cells surrounding large B-cells in NLPHD?
What NS HD variant has prominent aggregates of R-S cells?
Lymphomatoid Granulomatosis findings?
- 1) EBV immunoblasts are CD20+
- 2) Variable CD30+ but CD15-
- 3) Background CD4>CD8 T-cells
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