pharm endo 2/3

Card Set Information

Author:
merazar15
ID:
230936
Filename:
pharm endo 2/3
Updated:
2013-08-22 16:29:34
Tags:
growth hormone antagonist
Folders:

Description:
pharm endo 2/3, growth hormone antagonists
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user merazar15 on FreezingBlue Flashcards. What would you like to do?


  1. description:
    GH antagonists block the action of GH
  2. drugs:
    Pegvisomant (Somavert)
  3. indication
    • Acromegaly·      
    •    MC cause: Benign GH (hyper)secreting pituitary adenoma
    •    For patients with persistently elevated IGF-1 despite other therapy
    •    May be monotherapy option
  4. dose of pegvisomant is based on:
    serum IGF-1 conc
  5. kinetics:
    • The addition of PEG-500 to GH ·        
    •     Increases its half-life from 30 minutes to about 2 days
    • As a protein·         
    •      It cannot be taken orally
    •          Injected subcutaneously
  6. CI
    severe liver disease
  7. SE:
    • elevated liver enzymes (transaminases)
    •    25% of pts
  8. adverse effects:
    • Central nervous system: ·        
    •     Pain (8% to 14%)
    • Gastrointestinal: ·        
    •     Diarrhea (≤14%)·        
    •     Nausea (≤14%)
    • Local:
    •     Injection site reaction (4% to 11%)
    • Miscellaneous: ·        
    •     Infection (≤23%)·        
    •     Flu-like syndrome (4% to 12%)
  9. somatostatin:
    Normalizes IGF-1 levels in about 65% of patients
  10. Pegvisomant:
    • Normalized IGF-1 levels in 97% of patients
    • Reduced insulin and resting glucose levels but not HbA1c
    • Doubled GH levels

What would you like to do?

Home > Flashcards > Print Preview