pharm endo 2/3

Card Set Information

Author:
merazar15
ID:
230939
Filename:
pharm endo 2/3
Updated:
2013-08-22 16:43:09
Tags:
Adrenocorticotropic hormone ACTH
Folders:

Description:
pharm endo; ACTH
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  1. description:
    • secreted by the anterior pituitary
    •     acts on the adrenal glands
  2. drugs:
    • ACTH (Cosyntropin)
    •     
    • ·         Adrenocortical insufficiency diagnosis ·         Single dose of 0.25 mg IV over 6 hrs
  3. kinetics:
    half-life of 10 mins
  4. indication:
    • ACTH test:·        
    •     Test adrenal gland function
    •      Stimulates the adrenal gland
    •      Appropriate response is a rise in serum cortisol
  5. SE:
    Minimal when used as a single bolus test
  6. Tx for adrenal insufficiency:
    • Cortisol deficiency (primary and secondary)
    •     Hydrocortisone (Cortef)
    •     Prednisone (Deltasone)·        
    •     Prednisolone (Delta-Cortef)
    •     Methylprednisolone (Medrol)
    •     Dexamethasone (Decadron)
    • Mineralocorticoid deficiency (low aldosterone)
    •     Fludrocortisone Acetate
  7. which tx is preferred?
    • hydrocortisone
    • able to minimic adrenal secretion
    • able to titrate level

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