Describe the structural subunits of the CFTR protein and what regulates its function.
There are 2 membrane spanning domains (each with 6 membrane spanning alpha helices), 2 nucleotide binding domains (one after each membrane spanning domain), a regulatory domain where phosphorylation occurs, and a carboxyl terminal where binding to the cytoskeleton, other ion channels, and signal transduction proteins occurs.
Activation is caused by phosphorylation through protein kinase A, and probably other kinases as well. A deletion in the first nucleotide binding domain is often related to the disease. (ΔF508)