Anti-inflammatory 2

Card Set Information

Author:
Neda317
ID:
231404
Filename:
Anti-inflammatory 2
Updated:
2013-09-11 22:13:22
Tags:
pharm
Folders:

Description:
Anti-inflammatory 2
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Neda317 on FreezingBlue Flashcards. What would you like to do?


  1. Name 4 Drugs used in Asthma
    • 1.Bronchodilators
    • 2.Xanthine Bronchodilators
    • 3.Anticholinergic Bronchodilators
    • 4.Corticosteroids
  2. example of
    alpha1, B1, and B2 agonist
    Epinephrine
  3. example of
    beta1 and beta2 agonistalpha
    Isoproterenol
  4. Bronchodilators are
    • ***beta2 agonist
    • beta1 and beta2 agonist
    • alpha1, B1, and B2 agonist
  5. different types of beta2 agonist  and drugs names
    • 1.Short acting B2 agonist:
    •   albuterol
    •   metaproterenol 
    •   terbutaline
    • 2.Long acting B2 agonist:
    •   Salmeterol
  6. MOA

    Bronchodilators:
    • Bind to B2 receptors in the lung --> stimulate
    • enzyme adenyl cyclase --> produce (cAMP) --> relaxation of the smooth muscle of the bronchi
  7. Bronchodilators indications
    Bronchospasms
  8. Bronchospasms
    Long acting (Salmetrol) is for
    prophylaxis only
  9. benefit of Aerosolics
    have low systemic toxicity potential
  10. example of 

    Xanthine Bronchodilators
    Theophylline

    Aminophylline
  11. MOA

    Xanthine Bronchodilators
    • It competitively inhibits phosphodiesterase 
    • (enzyme that metabolizes cAMP) --> increase
    • cAMP --> Relaxation of bronchial muscles
  12. Theophylline
     drug interactions
    • 1.Theophylline has a narrow therapeutic index
    • 2.Drugs that affect theophylline elimination-> increase theophyline toxicity
    • 3. Drugs that increase theophylline metabolism --> decrease theophylline effects:
  13. which drugs will increase 
    theophylline toxicity: by affecting elimination 
    • Macrolide: erythromycin
    • Quinolones: Ciprofloxacin
  14. Drugs that increase theophylline metabolism by decrease theophylline effects:
    • CNS depressants: Phenobarbital
    • Antiepileptics: Carbamezepine
    • Tobacco and marijuana
  15. Anticholinergic Bronchodilators are:
    M Blockers (Antimuscarinic)
  16. Antimuscarinic 

    side effects
    • Like Atropine (anticholinergics)
    • Dry mouth
    • constipation 
    • urinary retention 
    • tachycardia
    • mydriasis
  17. Anticholinergic Bronchodilators

    Indications :
    • 1.Drug of choice in bronchospasm caused by Beta blockers
    • 2. Adjunct bronchodilator inhaler in Asthma
  18. In case of B Blockers overdose:
    • M blockers are indicated to relieve bronchospasm
    • b/c B agonist will not be effective
  19. bronchodilation in acute asthma in COPD
    • Anticholinergic Bronchodilators
    • (M blocker)
  20. name 3 Inhaled Corticosteroids
    • Beclomethasone
    • Fluticasone
    • Triamcinolone
  21. name 1 oral corticosteroids
    Prednisone
  22. MOA
    corticosteroids
    • Antiinflammatory
    • 1.inhibit the release of inflammatory mediators: kinins,
    • histamine that cause airway narrowing
    • 2.inhibit the synthesis of leukotriene            --> thus
    • reducing bronchoconstriction and mucus secretion
  23. Corticosteroids 
    Indication:
    • Chronic bronchitis
    • Bronchial Asthma
    • Allergic rhinitis
  24. Corticosteroids 

    Contraindications
    Acute bronchospams
  25. Coticosteroids 

    Adverse reaction
    • abdominal distress, anorexia
    • unpleasant taste in the mouth
    • oral fungal infection or candidiasis
  26. local bronchodilation
    after inhalation
    Ipratropium (Antimuscarinic)
  27. Bronchodilators

    Adverse
    reactions:
    • Anxiety, tremors, headache, palpitations
    • tachycardia,
    • hypertension and arrhythmia
  28. Contraindications 

    Bronchodilators:
    Uncontrolled arrhythmia
  29. Steroid Indications
    • Chronic bronchitis
    • Bronchial Asthma
    • Allergic rhinitis
  30. Steroids Contraindications
    • Acute
    • bronchospams
  31. Steroids Adverse
    reactions:
    • abdominal distress, anorexia
    • unpleasant taste in the mouth
    • oral fungal infection or candidiasis
  32. Leukotriene Antagonists
    • Montelukast (the best)
    • Zafirlukast
  33. Leukotriene
    Antagonists
    Mechanism
    of Action:
    • Antagonists
    • at LTD4 receptors
  34. Lipoxygenase
    Antagonist
    Zileuton
  35. Lipoxygenase
    Antagonist 
    Mechanism
    of Action:
    • Antagonist
    • of all LTs
  36. Lipoxygenase
    Antagonist Indications:
    • Prophylaxis and chronic treatment of Asthma
    • Seasonal allergic rhinitis
  37. Adverse
    reactions:
    • Headache
    • Dental pain
    • GI distress
    • Rash
  38. singulair side effect
    nightmare
  39. Zileutin
    increases
    liver function yest (LFTs)
  40. Mast
    cell Stabilizers
    • Cromolyn
    • Nedocromil
  41. Mastcell Stabilizers MOA
    • Prevent degranulation of pulmonary mast cells
    • inhibit release of histamine, leukotriene from mast cells
    • No bronchodilator effect
  42. Mastcell Stabilizers 
    Indications:
    • Prevention of bronchospam
    • Prophylacticin exercise induced asthma
    • NOT ACUTE ATTACK
  43. what is a asthima drug that is NOT for ACUTE ATTACK
    • Mast
    • cell Stabilizers
  44. Mast
    cell Stabilizers
    Adverse effects:
    • Cough,
    • hoarseness
    • diarrhea,
    • myalgia
    • bad taste in the mouth after use of inhaler
  45. Monoclonal antibody
    Omalizumab
  46. name 1 Monoclonal antibody
    omalizumab (xolair)
  47. Monoclonal antibody
    MAO
    Binds to IgE receptors on the mast cell
  48. MOAD and MAB at the end of the drug is which group of drugs
    Monoclonal antibody
  49. Monoclonal antibody 

    Indications
    • Moderate to severe persistent asthma
    • Not acute attack
  50. Monoclonal antibody 

    Adverse reactions:
    • Local injection site irritation
    • headache
    • Increased rate of viral or respiratory tract infections
  51. Approach
    for Managing Asthma
    • Infants and young children
    • 5 years and younger
  52. Quick
    Relief:
    • Short acting B2 agonist
    • Inhaled Albuterol
  53. Maintenance for Long term Control
    Mild intermittent
     for children 5 and younger (C)and 
    adult and children older than 5 (A)

    <2 days/week
    <2 nights/month
    A & C: No daily medication needed
  54. Maintenance for Long term Control

    Mild persistent
    for children 5 and younger (C)and adult and children older than 5 (A)
    >2 days/week
    >2 nights/month
    • C: Low-dose inhaled beclomethasone
    • Or
    • Inhaled cromolyn Or Montelukast oral

    • A: Low-dose inhaled beclomethasone
    • Or
    • Montelukast and/or Cromolyn Or
    • theophylline
  55. Maintenance for Long term Control
    for children 5 and younger (C)and adult and children older than 5 (A)
    Moderate persistent
    Daily 
    >1 night/week
    • C: Low-dose inhaled beclomethasone +
    • Salmetrol or Montelukast
    • Medium-dose inhaled beclomethasone

    • A: Low-to-medium dose inhaled beclomethasone + Salmetrol
    • or Montelukast
  56. Maintenance for Long term Control
    for children 5 and younger (C)and adult and children older than 5 (A
    Severe persistent
    Daily
    Night:
    frequent
    • A & C:High-dose inhaled beclomethasone
    • +
    • salmetrol
    • +
    • oral prednisone
  57. Approach
    for Managing Asthma
    Adults
    and Children
    older
    than 5 years
    Short acting B2 agonist

    Inhaled Albuterol
  58. Goals
    of Therapy: Asthma Control
    • 1. Minimal or no chronic symptoms day or night
    • 2. Minimal or no exacerbations
    • 3. No limitations on activities
    • 4.Maintain normal pulmonary function
    • 5. Minimal use of short-acting inhaled B2-agonist
    • 6. Minimal or no adverse effects from meds
  59. Status Asthmaticus in Children
    ER
    Management and 
    In Severe attack not responding to inhaled drugs
    • 1.Supplemental Oxygen
    • 2.Inhaled Albuterol
    • 3.IV methylprednisone
    • 4.Nebulized Ipratropium (Anticholinergics)
    • Severe attack :
    • 5.IV or SC epinephrine is considered
  60. Antitussives
    Codeine (Opioid)
  61. **Nonopioid
    antitussives:
    dextromethorphan (Robitussin)

    Benzonatate
  62. Antitussives Mechanism
    of Action:
    Treat nonproductive cough and cough that interfere with sleep or daily activities
  63. Expectorants
    Guaifenesin
  64. MOA Expectorants
    • Decreae
    • the viscosity of the secretions
  65. Expectorants Indications
    • Treat
    • cough associated with common cold
    • and
    • upper respiratory infections
  66. Guaifenesin
    is not recommended
    • for persistent cough
    • associated
    • with smoking, asthma and emphysema
  67. Diluents
    and reason to use
    • water 
    • normal saline 
    • to dilute respiratory secretions 
    • administered by ultrasonic nebulizer
  68. Mucolytics
    Acetylcysteine (Mucomyst)
  69. Mucolytics
    action
    break down the mucoprotein molecules
  70. Mucolytics

    indication
    • Treatment
    • for thick or abnormal mucus in cystic fibrosis or atelectasis
  71. Acetylcysteine used for
    Antidote for acetaminophen (Tylenol) overdose
  72. Dornase alfa
    It is a Recombinant human DNase
  73. Dornase alfa drug of?
    Cystic fibrosis
  74. Dornase
    alfa is administered via
    a nebulizer
  75. name 2 Decongestants drugs
    • Pseudoephedrine  sudafed) 
    • Phenylephrine
  76. MOA
    Decongestants
    stimulate alpha1 receptors                              --> vasoconstriction
  77. decongestants 

    indication
    Nasal Congestion
  78. Mechanism
    of Action of Albuterol
    Beta 2 agonist

What would you like to do?

Home > Flashcards > Print Preview