Activation of Complement

Card Set Information

Author:
Neda317
ID:
231999
Filename:
Activation of Complement
Updated:
2013-08-30 00:04:03
Tags:
immuno
Folders:

Description:
Activation of Complement
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Neda317 on FreezingBlue Flashcards. What would you like to do?


  1. The
    first white blood cell to reach to the site of inflammation
    the neutrophils then monocytes which differentiate into tissue macrophage
  2. GM-CSF (granulocyte-macrophage colony
    stimulating
    the neutrophils then monocytes which differentiate into tissue macrophage
  3. what factors can induce monocyte to differentiate into a dendritic cell
    • GM-CSF (granulocyte-macrophage colony
    • stimulating factor and IL-4 
  4. •to express E-selectin, P selectin,
    ICAM-1 and VCAM-1,
    • TNF,IL-1,IL-6: TNF and IL-1 induce post
    • capillary venules
  5. CXCL-1
    and CCL2
    • •bind
    • to neutrophils and monocytes and increase affinity of leukocyte affinity to
    • their endothelial ligands and stimulate their movement
  6. Actions
    of Cytokines in Inflammation 
    local inflammation endothelial cells
    • TNF, IL-1 --> leukocytes --> activation -->
    • IL-1, IL-6
  7. Actions
    of Cytokines in Inflammation 
    Systemic protective effects brain
    TNF, IL-1, IL-6 --> brain --> Fever
  8. Actions
    of Cytokines in Inflammation 
    Systemic protective effects liver
    IL-1, IL-6 --> Liver --> acute phase proteins
  9. Actions
    of Cytokines in Inflammation 
    Systemic protective effects bone marrow 
    TNF, IL-1, IL-6 --> bone marrow --> Leukocyte production
  10. Actions
    of Cytokines in Inflammation 
    systemic pathological effect heart 
    TNF --> Heart --> low output
  11. Actions
    of Cytokines in Inflammation 
    systemic pathological effect endothelial cells/blood vessel 
    TNF--> endothelial cells/blood vessel  --> thrombus and increase permeability
  12. Actions
    of Cytokines in Inflammation 
    systemic pathological effect multiple tissues
    TNF --> Skeletal muscle --> insulin resistance
  13. neutrophils bind to
    CXCL-1,2,3,8
  14. Monocytes bind to
    CCL2
  15. E & P selectin bind to
    SL on the surface of the neutophil
  16. CC: LAD-1 is due to
    defect in CD18 --> integrin function will be lost (LFA1 & Mac1)
  17. CC: LAD-2 is due to
    defect in SL
  18. Biologic
    Actions of Type I Interferons

What would you like to do?

Home > Flashcards > Print Preview