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How do Immature B cell become mature B
cells?
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what type of antigens activate B cells?
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What are the antigens recognized by
B cells and other lymphocytes?
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Thymus dependent
- 1.(Td): protein antigen requires help from TH cells
- TD antigens are proteins and recognized in conjunction with MHC molecules
B cells response to TD antigen requires direct contact with TH cells
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Thymus independentactivation
- 2.(Ti): does not require T cell help or thymus
- •Act by extensive cross linking of antigens
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what are the 3 major differences in response to Ti antigen
1.Response weaker
2.No isotype switch so only IgM formed
3.No memory cells formed
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what are the Subset of B cells
- Follicular B cells
- Marginal zone B cells
- B-1 B cells
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what kinds of B cell u can find in Spleen and other lymphoid organs?
Follicular and marginal B cells
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what kinds of B cell u can find in mucosal tissue, peritoneal cavity?
B-1 B cells
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Follicular B cells are:
•reside in the follicles of lymphoid organs make the bulk of T dependent, class switched, high affinity antibodies to protein antigens
protein antigen + TH cell
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Marginal zone B cells are:
•cells located in the marginal zones of splenic white pulp respond to blood borne polysacharide antigen; predominantly IgM
- polysaccharides, lipid, ...
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B-1 B cells are:
•respond to non protein antigen in the mucosal tissue and peritoneum; Ig M
- polysaccharides, lipid, ...
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