B lymphocyte activation and differentiation

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Author:
Anonymous
ID:
232151
Filename:
B lymphocyte activation and differentiation
Updated:
2013-08-31 12:52:43
Tags:
immuno
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Description:
Humoral Immune response
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  1. How do Immature B cell become mature B
    cells?
  2. what type of antigens activate B cells?
  3. What are the antigens recognized by
    B cells and other lymphocytes?
  4. Thymus dependent
    • 1.(Td): protein antigen requires help from TH cells
    • TD antigens are proteins and recognized in conjunction with MHC molecules

    B cells response to TD antigen requires direct contact with TH cells
  5. Thymus independentactivation
    • 2.(Ti): does not require T cell help or thymus
    • •Act by extensive cross linking of antigens
  6. what are the 3 major differences in response to Ti antigen
    1.Response weaker

    2.No isotype switch so only IgM formed

    3.No memory cells formed
  7. what are the Subset of B cells
    • Follicular B cells 
    • Marginal zone B cells 
    • B-1 B cells
  8. what kinds of B cell u can find in Spleen and other lymphoid organs?
    Follicular and marginal B cells
  9. what kinds of B cell u can find in mucosal tissue, peritoneal cavity?
    B-1 B cells
  10. Follicular B cells are:
    •reside in the follicles of lymphoid organs make the bulk of T dependent, class switched, high affinity antibodies to protein antigens

    protein antigen + TH cell
  11. Marginal zone B cells  are:
    •cells located in the marginal zones of splenic white pulp respond to blood borne polysacharide antigen; predominantly IgM

    • polysaccharides, lipid, ...
  12. B-1 B cells  are:
    •respond to non protein antigen in the mucosal tissue and peritoneum; Ig M

    • polysaccharides, lipid, ...

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