Atypical Antipsychotics

Card Set Information

Author:
Anonymous
ID:
232331
Filename:
Atypical Antipsychotics
Updated:
2013-09-01 19:20:51
Tags:
AAAA
Folders:

Description:
dvb
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Anonymous on FreezingBlue Flashcards. What would you like to do?


  1. Asenapine (Saphris)
    • §
    • Acute treatment of adults with schizophrenia and
    • acute
    • treatment of manic or mixed episodes associated with bipolar I disorder
    • with or without psychotic features in adults

    • §
    • Unique receptor profile

    • ·  
    • Strong antagonism D2, 5-HT2

    • ·  
    • Less affinity for M, H

    • §
    • Dose: 
    • 5-10 mg BID, sublingually               (due to 1st pass
    • metabolism)

    • §
    • Side effects: 
    • akathisia, oral hypothesia, somnolence, dizziness, extrapyramidal
    • symptoms, weight gain, insomnia, headache
  2. Iloperidone (Fanapt)
    • §
    • Acute treatment of adults with schizophrenia

    • §
    • High affinity: 
    • a1, D2, 5-HT

    • §
    • Low affinity: 
    • M

    • §
    • Dose: 
    • 6-12 mg BID, slow titration to avoid orthostatic hypotension

    • §
    • Side effects: 
    • dizziness, dry mouth, fatigue, nasal congestion, orthostatic
    • hypotension, somnolence, tachycardia, and weight increased.  Little EPS

    • §
    • QT prolongation: 
    • consider alternatives first, titrate, monitor, check for drug
    • interactions, electrolytes
  3. Paliperidone
    Palmitate (Sustenna) IM
    • §
    • Long acting injectable (oral is Invega)

    • §
    • Requires 2 deltoid injections 1 week apart
    • before 4 week injection in gluteal muscle

    • §
    • Low rates of weight gain and EPS

    • §
    • Cost is significant:  2 x oral paliperidone, 19 x generic
    • risperidone
  4. Lurasidone (Latuda) –
    Oct 2010
    • §
    • Acute treatment of adults with schizophrenia

    • §
    • High affinity: 
    • D2, 5-HT

    • §
    • Low affinity: 
    • M

    • §
    • Dose: 
    • 40-80 mg daily with food (>350
    • cal)**

    • §
    • Side effects: 
    • somnolence, akathisia, nausea, parkinsonism and agitation

    • §
    • Minimal weight gain and no clinically meaningful
    • alterations in glucose, lipids, prolactin or the ECG QT interval

    • §
    • Affinity for 5-HT 7 may play a role on cognition

    ** Like Geodon (zisprasidone) take with food
  5. Olanzapine (Zyprexa
    Relprevv)
    • §
    • Long acting injectable

    • §
    • Post injection delirium/sedation syndrome,
    • <0.1% of injection but requires 3 hour waiting period, observation at an
    • approved site, and a ride home

    • §
    • Dosing is based on oral dose, given every 2-4
    • weeks, gluteal injection

    • §
    • Similar side effects to oral preparation
  6. §
    Quetiapine (Seroquel XR)
    • Adjunctive treatment
    • of major depressive disorder (Dec 2009)
  7. §
    Olanzapine (Zyprexa)
    • ·  
    • Schizophrenia, bipolar (manic, mixed) in
    • adolescents 13-17 y.o. (Dec 2009)

    • ·  
    • With fluoxetine (Symbyax) acute treatment of
    • treatment-resistant depression (Mar 2009)
  8. §
    Aripiprazole (Abilify) MDD approval 8/12
    • ·        
    • Irritability associated with autistic disorder
    • in pediatric patients 6-17 y.o. (Nov 2009)
  9. §
    Ziprasidone (Geodon)
    • ·        
    • Maintenance
    • treatment of bipolar I disorder as an adjunct to lithium or valproate in adults
    • (Nov 2009)
  10. §
    Paliperidone (Invega)
    • ·        
    • Acute treatment of schizoaffective disorder
    • either as monotherapy or adjunctive therapy (Aug 2009)

    • ·        
    • Long acting (Sustenna), acute and maintenance
    • treatment of schizophrenia in adults (Aug 2009)
  11. §
    Risperidone (Risperdal)
    • ·        
    • Long acting (Consta), monotherapy or as
    • adjunctive therapy to lithium or valproate in the maintenance treatment of
    • bipolar I disorder (May 2009)

    • ·        
    • Also oral can be used in acute manic or mixed
    • episode
  12. §
    Asenapine (Saphris)
    • ·        
    • Monotherapy or adjunctive in manic and mixed
    • bipolar I (Sept 2010)

What would you like to do?

Home > Flashcards > Print Preview