255 immune response

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elevatedsound7
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255 immune response
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2013-09-05 12:49:21
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255 immune response
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255 immune response
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  1. local signs of inflammatory response
    • redness
    • edema
    • heat
    • pain
    • loss of function
  2. fibrin =
    strengthens a blood clot formed by platelets
  3. lymphocytes =
    • WBC
    • involved in immune response
  4. mononuclear phagocytes =
    • (include monocytes and macrophages)
    • phagocytes that engulf antigen to destroy or function as a cell that presents antigen to T and B cells
  5. Dendritic cells =
    cells that capture antigen and transport antigen to a specific antigen
  6. Diapedisis
    the passage of blood cells through the intact walls of the capillaries, typically accompanying inflammation.
  7. margination
    Margination is the process in which free-flowing leukocytes exit the central blood stream, and initiate leukocyte and endothelial cell interactions by close mechanical contact
  8. chemotaxis =
    • directional migration of WBCs to the site of injury
    • results in accumulation of neutrophils an monocytes at site of injury
  9. neutrophils are
    • first leukocytes to arrive at site of injury
    • they phagocytize bacteria
  10. blood discrasia =
    nondescript problem with blood cells
  11. shift to left =
    • elevation in bands in pt blood
    • elevation of juvenile WBC
    • acute infection
  12. neutrophils arrive when
    6 - 12 hours
  13. life span of neutrophil
    24 - 48 hours
  14. monocytes=
    second type of phagocytic cells to migrate to site of injury
  15. monocytes arrive when
    3 - 7 days after onset of inflammation
  16. macrophages are important
    in cleaning the area befroe healing can occur
  17. primary roles of lymphocytes involve
    • cell-mediated immunity
    • humoral immunity
  18. histamine is released from
    the mast cell
  19. histamine causes
    • vasodilation
    • increased capillary permeability
    • smooth muscle constriction in the bronchials
    • tissue swelling and itching
  20. chemical mediators are
    • bioactive substances that are involved in the vascular and cellular responses
    • ie histamine and serotonin
  21. Serotonin =
    • chemical mediator
    • vasodilation
    • increased capillary permeability
    • smooth muscle contraction
  22. thromboxane =
    • chemical mediator
    • powerful vasoconstriction and cause of initial skin pallor at injury site
    • platelet aggregating agent
    • promotes clot formation
  23. Leukotrienes form
    • the slow reacting substance of anaphylaxis
    • constricts smooth muscle of bronchi
    • increases cap. permeability
    • stimulates chemtaxis
  24. arachadonic acid is
    • chemical in cell membrane that is converted into
    • prostaglandins
    • thromboxane
    • leukotrienes
  25. when you think kinin you should think
    stimulation of the pain receptors
  26. complement cascade =
    • cluster of 20 plasma proteins that combine in sequential order than causes
    • vasodilation
    • increased permeability
    • leukocyte chemotaxis
    • phagocytosis
    • stimulate the release of histamine
  27. when you have inflammation you have increase of protein levels why
    • complement cascade which is made up of 20 different proteins and it is integral in inflammatory response
    • so you have elevated levels of C reactive protein
  28. cytokines do what
    • sound the alarm for the immune response cells
    • messengers that tell the cells what to do
    • intsruct cells to alter their proliferation, differentiation secretory, or activity
  29. hematopoiesis =
    making of blood cell s
  30. serous exudate =
    • early inflammation
    • blister
  31. serosanguinous exudate =
    RBCs and serous
  32. fibrinous exudate =
    adhesions, gelatinous exudate
  33. purulent exudate =
    • WBCs
    • microorganisms
    • dead cells
    • abscess
  34. catarrhal exudate =
    • mucus
    • runny nose
  35. acute inflammation lasts
    1-2 weeks
  36. subacute inflammation =
    • has same features as acute inflammation but persists longer
    • ie acute endocarditis
  37. 3 functions of immunity =
    • defense
    • homeostasis
    • surveillance
  38. are b lymphocytes humurol or cell mediated immune response
    humural
  39. are T cells part of humural or cell mediated immune response
    cell mediated
  40. T lymphocytes go after antigens that are where
    • in the cell
    • ie viruses
    • cancer

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