Ch1: Amino Acids
Card Set Information
Ch1: Amino Acids
Polar AA's (☗) cluster on
surface of soluble proteins
Nonpolar AA's (O) cluster on
surface of membra
interior of soluble
in lipid environment
Slide 10: Proline has a
N Amino group attached to left.
⇒Alanine has a ___________ amino group attached.
Slide 11: Tyrosine has which bond between it's hydroxyl group and another molecule containing carbonyl group?
L-Alanine cells are in
D-Alanine type of cell is in
in bacteria cells
found in antibiotics, and plant cells
Cells that are mirror images of each other
D & L forms of Alanine.
L-Al has (H
D-Al has (NH
PH lower than 7 is
PH greater than 7 is
»Losing proton, losing H.
»When PH increases; H is lost; Carboxilic group loses 1st.
Buffer zone is calculated as
/- = 3.8 to 5.8
Calculate Buffer zone and PI with 2 buffer zones given as pK
=2.3, and pK
Buff zone 1: 2.3 -+ 1=
1.3 to 3.3
Buff zone 2:
8.1 to 10.1
⇰Take # before neutral for pK1
⇰Take # after neautral for pK2
More practice on slides 26-28
AA titration: PI>PH
overall charge is (+)
AA titration: PI<PH
The overall charge is (-)
AA titration: PH=PI
The overall charge is (0)
Increase in bicarb ion cause ph to
Pulmonary obstruction causes increase in _____ and decrease in _______
Decrease in pH
Stomach has a pH of 1.5, aspirin has a pH of 3.5 (weak acid); therefore, it will be protonated (COOH) and thus ________
Uncharged drugs cross membranes more _______ than charged molecules.
Morphine is uncharged, usually passes through cell membrane more ______ than charged form.
Ionized or charged form of drugs which are weak acid or weak base can't cross the biological cell membrane due to the.
Non polar Lipid bi-layer.
2 buffering systems
2. Bicarbonate system
Good PH is between
7.37 and 7.43
caused by hypoventilation,
low Resp Rate.
In Airway obstruction
In neuromuscular disorders
In central nervous system disorder
Caused by hyperventilation,
INC Resp Rate.
Excessive elimination of CO
and pH is INC.
In Salicylate poisoning
In High altitude (dec. atmosphere pressure, and alveolar PCO
Acid accumulation in blood, Low pH, Dec. Bicarbonate.
Equilibrium shift toward carbonic acid
Carbonic anhydrase converts to CO
and water then co2 is exhaled.
In Meds taken
In excess lactic acid
In acetoacetic acid, B-hydro acid
In ingestion of salicylates, ethylene glycol, methyl alcohol
accumulation of bicarbonate in blood
Protons lost from blood
carbon equil. with CO2 shifts toward carbonic acid
carbonic acid converts to bicarbonate and restores protons.
As a result there is accumulation of bicarbonate in blood
In increased diuretics
In loss of chloride ions from vomiting
In giving to much sodium bicarbonate
pH 7.35-7.45 bicarbonate/carbonic acid ratio is 20:1 (usual)
Low pH, bicarb to carbonic acid ratio 20:4
Low pH, Bicarbonate to carbonic acid is 15:1 (Lowered bicarbonate)
pg12 #1.2: Cysteine is able to form ____________ bond
Pg 12 #1.3: Gly has PI of 6.1 and pH2. which electrode will Gly move in electric field, neg or pos?
Gly is +
It will move toward
pg1. Each amino acid has (except for proline which has secondary amino group)
1. carboxyl group
2. primary amino group
3. a side chain "R group" bonded to alpha carbon atom
Pg5: amino acids with acidic side chains
Aspartate and glutamate; they are negative charged.
Pg 5: AA with basic side chains
Lysine and Arginine. Also Histidine (weak basic) depending on environment.
pg 6: proton acceptor