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Mechanism of Action
Inhibits central nervous system (CNS) catecholamine receptors: strong antidopaminergic and weak anticholinergic. Acts on CNS to depress subcortical areas, mid-brain and ascending reticular activating system in the brain.
Acute psychotic episodes
Agitation secondary to shock or hypoxia. Hypersensitivity
Extrapyramidal signs and symptoms, restlessness, spasms, Parkinson-like symptoms, drooling, dystonia, hypotension, orthostatic, hypotension, nausea, vomiting, blurred vision.
Enhanced CNS depression and hypotension in combination with alcohol. Antagonized amphetamines and epinephrine. Other CNS depressants may potentiate effects.
5 mg/ml ampule.
Dosage and Administration
- Adult: 2-5 mg IM every 30-60 minutes until sedation achieved.
- Pediactric: Not recommended.
Duration of Action
- Onset: 10 minutes.
- Peak Effect: 30-45 minutes.
- Duration: variable (generally 12-24 hours).
Pregnancy safety: not established. Treat hypotension secondary to Haldol with fluids and norepinephrine, not epinephrine. Patient may also be taking Cogentin (benztropine mesylate) if on long-term therapy with Haldol.
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