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Amiodarone - Generic name:
Amiodarone - Trade name:
Amiodarone - Class:
Amiodarone - Actions/pharmacodynamics:
- 1) Prolongs action potential duration in all cardiac tissues
- 2) Blocks sodium channels at rapid pacing frequencies
- 3) Blocks myocardial potassium channels which slows conduction and prolongs refractory period
- 4) Potent vasodilation
Amiodarone - Indications:
- 1) Pulseless v-tach and v-fib
- 2) Polymorphic v-tach
- 3) SVT refractory to Adenosine
- 4) wide complex tachycardia of unknown etiology
Amiodarone - Contraindications:
- 1) Cardiogenic shock
- 2) Severe sinus node dysfunction indicated by bradycardic condition (sinus bradycardia and 2nd and 3rd degree heart blocks)
- 3) Symptomatic bradycardia
- 4) Allergy to medication
Amiodarone - Precautions:
- 1) Use with caution in patients with latent or manifest heart failure. Exacerbates condition.
- 2) Use with caution in renal failure patients.
Amiodarone - Side effects:
- 1) Monitor ECG
- 2) Hypotension, possibly prolonged following conversion from v-fib
- 3) Negative inotropic and chronotropic
- 4) Increased ventricular beats
- 5) Prolonged PR interval, QRS complex, and QT interval
- 6) Be alert for signs of pulmonary toxicity (dyspnea and cough)
Amiodarone - Adult dosage:
- Cardiac arrest. 1st dose: 300 mg over 5 - 10 minutes. 2nd dose: 150 mg. Maximum cumulative of 2.2 g / 24 hours.
- Wide complex stable tachycardia. 150 mg IV push over 10 minutes (15 mg / min)
- Slow infusion. 360 mg IV over 6 hours (1 mg / min) OR mix 100 mg in 100 mL normal saline, infuse at 1 mg / min (60 gtts / min)
Amiodarone - Route:
Amiodarone - How supplied:
150 mg / 3 mL
Amiodarone - Pediatric dosage:
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