pharm ch 3 notes pharmacokenitic neonatal and pediatric considerations

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ajax726
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234453
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pharm ch 3 notes pharmacokenitic neonatal and pediatric considerations
Updated:
2013-09-12 09:28:25
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104 exam two
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  1. absorption: (4)
    • gastric pH less acidic
    • gastric emptying slowed
    • intramuscular absorption faster and irregular
    • first pass is reduced due to immature liver and reduced microsomal enzymes
  2. distribution: (3)
    • greater total body water means lower fat content
    • decreased level of protein binding due to immature liver
    • immature blood brain barrier - more drugs enter the brain
  3. metabolism: (5)
    • liver immature, does not produce enough microsomal enzymes
    • older children may have increased metabolism, requiring higher doses than infants
    • genetic factors
    • maternal exposure to substances
  4. excretion: (2)
    • kidney immaturity affects glomerular filtration rate and tubular secretion
    • decreased perfusion rate of the kidneys may reduce excretion of drugs

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