pharm ch 3 pharmacokinetic considerations of the elderly

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Author:
ajax726
ID:
234455
Filename:
pharm ch 3 pharmacokinetic considerations of the elderly
Updated:
2013-09-12 09:36:18
Tags:
pharm exam two
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  1. absorption: (6)
    • gastric pH less acidic
    • gastric emptying slowed
    • movement through GI tract slowed
    • blood flow to GI tract reduced
    • reduced absorptive surface area due to flattened intestinal villi
    • use of laxatives may accelerate GI motility
  2. distribution: (3)
    • lower total body water percentages
    • increased fat content
    • decreased production of proteins by the liver, resulting in decreased protein binding of drugs (and increased circulation of free drugs)
  3. metabolism: (2)
    • aging liver produces fewer microsomal enzymes, affecting drug metabolism
    • reduced blood flow to the liver
  4. excretion: (2)
    • decreased glomerular filtration rate
    • decreased number of intact nephrons

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