Pharm Exam 1

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skcook2
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234684
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Pharm Exam 1
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2013-09-14 20:24:26
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Pharm Exam
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Pharm Exam 1
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  1. Describe the "perfect" drug
    effective, safe, selective, reversible action, predictability, ease of administration, minimal drug interactions, low cost, chemical stability, simple generic name
  2. What is drug tolerance?
    Larger dose of the drug needed to achieve the same effect
  3. The study of drugs in humans is referred to as...
    clinical pharmacology
  4. The study of drugs and their interactions with living systems is the definition of ...
    pharmacology
  5. ... is defined as the use of drugs to diagnose, prevent, or treat disease or to prevent pregnancy
    Therapeutics or/and pharmacotherapeutics
  6. Any chemical that can affect living processes is a ...
    ... drug
  7. The three most important characteristics that any drugs can have are...
    ...effectiveness, safety and selectivity
  8. The Greek word pharmakon is translated as ...
    ... poison
  9. The objective of drug therapy is to provide ...
    ... max benefit with minimum harm
  10. The four major pharmacokinetic processes are ...
    ... absorption, distribution, metabolism, and excretion
  11. Pharmacodynamics may be thought of as ...
    ... the impact of the drug on the body
  12. This term refers to the ability of a drug to reach the systemic circulation from its site of administration.
    bioavailability
  13. A group of signs and symptoms associated with exposure to a particular substance or class of substances.
    Toxidromes
  14. The study of how genes affect individual drug responses...
    ... pharmacogenomics
  15. The study of drug movement through the body...
    ... pharmakinetics
  16. The therapeutic range of a drug lies between...
    ... the minimal effect and the toxic effect
  17. The study of the biochemical and physiologic effects of drugs and the molecular mechanisms by which those effects are produced...
    ...pharmacodynamics
  18. The amount of drug we must give to elicit an effect is called...
    potency
  19. The function of the transcription factors is to ...
    ...regulate protein synthesis
  20. Molecules that activate receptors that mimic the action of endogenous molecules
    agonists
  21. Prevents receptor activation...
    ... antagonist
  22. Binds reversibly by highest concentration
    competitive receptors
  23. Binds irreversibly for the life of the cell
    non-competitive receptors
  24. The study of drugs that alter the process controlled by the nervous system...
    ... neuropharmacology
  25. What are the only drugs that are proven to work by altering or decreasing axonal conduction?
    Local anesthetic
  26. Beta 1 Receptor responses:
    heart stimulation, increase force of contraction
  27. Beta 2 Receptor responses:
    bronchodilation, relaxation of uterine muscle (slow labor)
  28. Functions of the parasympathetic nervous system:
    GI motility, slow HR, increase glandular and respiratory secretions, constrict bronchioles, constrict pupils
  29. Functions of the sympathetic nervous system:
    increase BP, HR, shunt blood from skin to organs at core, bronchial and pupil dilation, release stored energy
  30. Alpha 1 Receptor responses:
    vasculature, vasoconstriction, pupil dilation, ejaculation, contraction of bladder neck and prostrate
  31. Alpha 2 Receptor responses:
    located in presynaptic junction, minimal clinical significance
  32. 3 Neurotransmitters used by the peripheral nervous system:
    acetylcholine, norepinephrine, epinephrine
  33. 3 Cholinergic Receptors:
    • Nicotinic n (neuronal)
    • Nicotinic m (muscle)
    • Muscarinic (organs)
  34. 3 Muscarinic (muscle) subtypes:
    • M1 - Salivary/CNS
    • M2 - Heart
    • M3 - Salivary, GI, Bladder and Eye
  35. Muscarinic:
    What system?
    What receptors?
    What responses?
    • PNS
    • Nictotinc N, M and Muscarinc
    • Pupil constriction, increase GI motility & secretions, HR slow down, lungs increase secretions
  36. What is the drug of choice for bradycardia?
    Atropine

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