255 general anti-infective

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Author:
elevatedsound7
ID:
235360
Filename:
255 general anti-infective
Updated:
2013-09-17 12:46:06
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255 general anti infective
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255 general anti-infective
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  1. how are anti-infective drugs classified
    • their susceptible organism
    • chemical structure
    • mechanisms of action (ie = inhibition of cell wall synthesis
  2. bacteriocidal vs bacteriostatic =
    • cidal - kills
    • static - inhibits growth
  3. mechanisms of action of antimicrobial drugs
    • cell wall synthesis inhibitors
    • DNA synthesis inhibitors
    • Antimetabolites
    • Protein synthesis inhibitors
    • RNA synthesis inhibitors
  4. mechanism of resistance by bacteria
    • destroy drug (enzyme production)
    • prevent drug entering pathogen
    • remove drug via resistance pumps
    • alter drug's target site
    • develop alternative metabolic pathways
  5. MRSA is still sensitive to
    Vancomycin
  6. MRSA that are resistant to vancomycin may have susceptibilty to
    linezolid (zyvox)
  7. VRE =
    vancomycin-resistant enterococci
  8. can antiinfectives be given prophylacticly
    • yes ie
    • surgery
    • dog bitesHIV-AIDS
    • prosthetic heart valves
    • anti-malarial etc
  9. General nursing consideration with administrations of anti-infectives
    • allergy
    • anaphylactic reaction
    • co-mobidities
    • BUN, creatinine
    • ALT AST - elevation = liver pathology
    • WBC, C&S, UA
    • VS
    • superinfection - vaginal itching, oral white patches
  10. typical GI effects of antibiotics
    • N/V
    • diarrhea
    • abdominal pain
    • decreased LOC
  11. typical neurological effects of antibiotics =
    • drowsiness
    • dizziness
    • headache
    • decreased LOC
  12. nephrotoxicity effects of antibiotics =
    • decreased UOP
    • dark urine
    • weight gain (>2.2lbs in a day)
  13. hepatotoxicity in antibiotics =
    • jaundice
    • fatigue
    • light colored stool
    • dark urine

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