blood Coagulation

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Author:
Neda317
ID:
235502
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blood Coagulation
Updated:
2013-09-17 22:56:58
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platelet
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  1. Coagulation Factors
    I (fibrinogen)
    Forms clot (fibrin)
  2. Coagulation Factors
    II (prothrombin)
    • Active form (IIa) activates I, V, VII, VIII, XI, XIII,
    • protein C, platelets
  3. Coagulation Factors
    III (Tissue factor)
    Co-factor of VIIa
  4. Coagulation Factors
    IV (Calcium)
    • Required for coagulation factors to bind
    • to phospholipid
  5. Coagulation Factors
    V (labile factor, proaccelerin)
    Co-factor of X
  6. Coagulation Factors
    VI
    Unassigned – old name of Factor Va
  7. Coagulation Factors
    VII (stable factor, proconvertin)
    Activates IX, X
  8. Coagulation Factors
    VIII (antihemophilic factor A)
    Co-factor of IX
  9. Coagulation Factors
    IX (antihemophilic factor B or Christmas factor)
    Activates X
  10. Coagulation Factors
    X (Stuart-Prower factor)
    Activates II: forms prothrombinase complex with V
  11. Coagulation Factors
    XI (plasma thromboplastin antecedent)
    Activates IX
  12. Coagulation Factors
    XII (Hageman factor)
    Activates XI, VII and prekallikrein
  13. Coagulation Factors
    XIII (fibrin-stabilizing factor)
    Crosslinks fibrin
  14. Coagulation Related Substances
    von Willebrand factor
    Binds to VIII, mediates platelet adhesion
  15. Coagulation Related Substances
    Antithrombin III
    Inhibits IIa, Xa, and other proteases
  16. Coagulation Related Substances
    Protein C
    Inactivates Va and VIIIa
  17. Coagulation Related Substances
    Protein S
    Cofactor for activated protein C (APC)
  18. Coagulation Related Substances
    Plasminogen
    Converts to plasmin, lyses fibrin
  19. Coagulation Related Substances
    α 2-antiplasmin
    Inhibits plasmin
  20. Coagulation Related Substances
    Thrombomodulin
    • Activates protein C, blocks coagulation
    • cascade
  21. Coagulation Related Substances
    Tissur
    factor pathway inhibitor (TFPI)
    • Inhibits tissue factor-factor VIIa and
    • factor Xa activities
  22. Coagulation Related Substances
    Tissue plasminogen activator (t-PA)
    Activates plasminogen
  23. Coagulation Related Substances
    Plasminogen
    activator inhibitor-1 (PAI-1)
    Inactivates t-PA (endothelial PAI)
  24. Coagulation Related Substances
    Plasminogen activator inhibitor-2 (PAI-2)
    Inactivates t-PA (placental PAI)

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