HISTO BLOCKII

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Author:
nikistrow
ID:
235615
Filename:
HISTO BLOCKII
Updated:
2013-09-18 14:39:51
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Histo Block II
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    • Normal blood smear
    • pale centre-RBCs
    • arrows to PLATELETS
    • nucleus staining blue(top left corner) WBC EOSINOPHIL
    • cytoplasm not stained (top right corner and bottom right)-WBC Neutrophil
    • RBCs in single file within capillary
    • A is adipocytes
  1. RBCs do not have nuclei
  2. SEM of normal RBCs
    • Cross section of RBC
    • Platelet at the bottom
  3. SEM of RBCs
  4. Rouleux-stacks of RBCs formed by increased levels of plasma immunoglobulins
    • Rouleux
    • RBCs
    • Echinocytes
    • Echinocytes 
    • Formed by aged blood, increased EDTA to blood ratio, drugs, uremia, rattle snake venom
  5. CRENATED RBCs are dehydrated RBCs
    • Spherocytosis is caused by defect in cytoskeletal proteins
    • Primarily from defect in spectrin gene expression giving spherical
    • erythrocytes result
    • RBCs are small   
    • Central zones lacks pallor
    • Lack of spectrin produces
    • spheres and RBCs rupture / hemolysis
  6. SEM of Normal RBC-spherocytosis leading to hemolysis and crenation
    • ANEMIA
    • RBCs here are smaller than normal and have an increased zone of central pallor.
    • hypochromic (less hemoglobin in each RBC)
    • microcytic (smaller size of each RBC)  
    • anisocytosis (variation
    • in size) 
    • poikilocytosis (variation in shape).

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