HIST BLOCK II BLOOD

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Author:
nikistrow
ID:
235975
Filename:
HIST BLOCK II BLOOD
Updated:
2013-09-20 05:37:56
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blood slides
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slides 100-150
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  1. A large lymphocyte and several erythrocytes. The nucleus of this cell is round, and the cytoplasm is devoid of specific granules.

    Giemsa stain. High magnification.
  2. Monocyte
    • Monocyte.
    • This cell type has a kidney-shaped nucleus with delicately stained chromatin. The cytoplasm is slightly basophilic. Giemsa
    • stain. High magnification.
    • There are also azurphillic granules
    • TEM: A human monocyte.
    • the Golgi complex (G), the
    • mitochondria (M), and the lysosomes or azurophilic granules (A).
    • Rough endoplasmic reticulum is poorly
    • developed.
    • There are some free ribosomes (R).
    • x22,000.
  3. Monocyte
  4. Monocyte
  5. overview
    • thrombocytes/platelets
    • MEGAKARYOCYTES
    • thrombocytes/platelets
    • MEGAKARYOCYTES
    • PLATELET DEMARCATION CHANNELS
    • Platelet demarcation channel membranes are invaginations of the plasma  membrane
    • PLATELETS therefore form from  segmentation of parts of the megakaryocyte 
    • cytoplasm
    • Thrombocytes/Platelets
    • portion of megakaryocyte with platelet demarcation channels the channels are continuous with
    • the extracellular space
    • Platelet/Thombocyte
    • platelet demarcation channels, lobes of the nucleus, mitochondria
    • Platelet/Thombocytes
    • Platelets may be divided into 4 zones
    • Peripheral zone
    • -cell membrane covered by thick glycocalyx
    • -glycocalyx contains glycoproteins, gycosaminoglycans and coagulation factors
    • Platelets/Thrombocytes ZONES
    • Structural zone
    •    -  microtubules, actin, myosin, actin-binding proteins
    • -circumferentially arranged
    • -responsible for cell shape
    • Platelet/Thrombocytes ZONES
    • Organelle zone
    • -centrally located
    • -mitochondria, peroxisomes, glycogen particles, granules.
    • Platelets/Thrombocytes ZONES
    • Membrane zone
    • 2  types of membrane channels
    • -  open canalicular system (OCS) (remnant of the platelet demarcation channel )
    • -  dense tubular system (DTS)  (storage site for calcium)
    • Thrombocyte/Platelets
    • Platelet between RBC on left  and endothelial cell on the right
  6. RBCs adjacent to a platelet
  7. Overview of Platelet ZONES
    • Platelet/Thrombocytes
    • Platelets are involved with blood clot formation
    • Fibrinogen is converted to fibrin
    • Red blood cells trapped in fibrin forming a hemostatic plug
  8. thrombi/ throboemboli
  9. lymphocyte, monocyte, basophil, eosinophil, band neutrophil (stab), mature neutrophil, platelet, erythrocytes.
  10. platelets, large lymphocyte, neutrophil, RBCs
  11. band neutrophil, mature segmented neutrophil, platelets.
  12. eosinophil,  neutrophil, platelets

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