histology of blood part I A

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sabamed
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236026
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histology of blood part I A
Updated:
2013-09-20 19:28:52
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block II saba sabamed hematopoiesis hemopoeisis
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histology block II
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  1. Label. Where is this from?
    • Top hematocytes
    • Middle Spine (drain)
    • Bottom: Sinusoids
    • Liver


  2. Where is this from? What does it indicate? When does this NORMALLY occur?
    This is from liver. See hematocytes cells indicate hematopeoisis is occurring.  2nd trimester (3-6 months)

  3. Where is this from? What does it show?
    This is from bone marrow. Note that white globs are adipose cells. Varied cells indicate active and normal hematopoiesis.

  4. Label

  5. What cell is this and what are it's main characteristics?
    PROERYTHROBLAST–First microscopically recognizable cell–Large, 12-20 µm diam–spherical nucleusn1 or 2 nucleoli–Lightly basophilic cytoplasm nfree ribosomes
  6. nBASOPHILIC ERYTHROBLAST  -  from mitoses of proerythroblast  - smaller nucleus and more heterochromatin  - Cytoplasm is strongly basophilic  - due to free ribosomes (polyribosomes) synthesizing hemoglobin   - the accumulation of hemoglobin changes staining of cytoplasm to eosinophilic
  7. nBASOPHILIC ERYTHROBLAST  -  from mitoses of proerythroblast  - smaller nucleus and more heterochromatin  - Cytoplasm is strongly basophilic  - due to free ribosomes (polyribosomes) synthesizing hemoglobin   - the accumulation of hemoglobin changes staining of cytoplasm to eosinophilic
    • A: Orthochromatophilic erythoblast
    • B. Neutrophil
    • C. Orthochromatophilic erythroblast aka normal blast
    • Bottom Left: RBC
    • Bottom Right: Normal blast
    • A: Erythrocytes
    • B. Polychromatic erythrocytes aka Reticulocytes (ribosomes make it slightly more basophilic).
    • C. Reticular lines.

  8. Label A & B. What is a nickname for cell A and why is it called that? What is it called when you have too much?
    B. RBC. A. polychromatophilic erythrocyte reveals a reticular network of the polyribosomes The cells are therefore also known as RETICULOCYTES. More than 1-2% of reticulocytes (reticulocytosis) indicate blood loss

  9. What is A? What will it turn into?And how long before it reaches the next stage?
    A: Reticulocytes(1 more day for maturation to RBCs)

  10. What is this a photo of?
    Mature erythrocytes and a few platelets
  11. A. Fimbrae of a Polychromatic eurythrocyte. You can see endosomes & mitochondria inside.
  12. Label
    • A. Eurythroblast
    • C. Mature Erythrocyte
    • Hint: exact same size except Eyrythroblast still has nucleus.
  13. RBC formation is controlled by what glycoprotein hormone? Where is it made and under what condition?
    ERYTHROPOIETIN    -  synthesized and secreted by kidney    -  responds to ↓ levels of O2 in the blood.
  14. How long does it take RBC to get old? What happens to it?
    120 days. Macrophage system of spleen, liver and  bone marrow   -  phagocytose and degrade      senescent (old) RBCs
  15. How does Hemoglobin breakdown?
    • Hemoglobin =heme + globin.
    • Globin amino acids are reused.
    • Heme releases Fe, which converts into hemosiderin or ferritin stored in SPLEEN for Hb synthesis
  16. Label:
    A:2 Large in the middle are Megakaryocyte with platelet demarcation channels making platelets.B. Immature  WBC and RBC (Hematopeitic cells)C.AdiposeD.Spongy bone (streams of bone)E.Osteocyte cells

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