histology of blood part I A

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    Label. Where is this from?
    • Top hematocytes
    • Middle Spine (drain)
    • Bottom: Sinusoids
    • Liver
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    Where is this from? What does it indicate? When does this NORMALLY occur?
    This is from liver. See hematocytes cells indicate hematopeoisis is occurring.  2nd trimester (3-6 months)
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    Where is this from? What does it show?
    This is from bone marrow. Note that white globs are adipose cells. Varied cells indicate active and normal hematopoiesis.
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    Label
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    What cell is this and what are it's main characteristics?
    PROERYTHROBLAST–First microscopically recognizable cell–Large, 12-20 µm diam–spherical nucleusn1 or 2 nucleoli–Lightly basophilic cytoplasm nfree ribosomes
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    nBASOPHILIC ERYTHROBLAST  -  from mitoses of proerythroblast  - smaller nucleus and more heterochromatin  - Cytoplasm is strongly basophilic  - due to free ribosomes (polyribosomes) synthesizing hemoglobin   - the accumulation of hemoglobin changes staining of cytoplasm to eosinophilic
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    nBASOPHILIC ERYTHROBLAST  -  from mitoses of proerythroblast  - smaller nucleus and more heterochromatin  - Cytoplasm is strongly basophilic  - due to free ribosomes (polyribosomes) synthesizing hemoglobin   - the accumulation of hemoglobin changes staining of cytoplasm to eosinophilic
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    • A: Orthochromatophilic erythoblast
    • B. Neutrophil
    • C. Orthochromatophilic erythroblast aka normal blast
    • Bottom Left: RBC
    • Bottom Right: Normal blast
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    • A: Erythrocytes
    • B. Polychromatic erythrocytes aka Reticulocytes (ribosomes make it slightly more basophilic).
    • C. Reticular lines.
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    Label A & B. What is a nickname for cell A and why is it called that? What is it called when you have too much?
    B. RBC. A. polychromatophilic erythrocyte reveals a reticular network of the polyribosomes The cells are therefore also known as RETICULOCYTES. More than 1-2% of reticulocytes (reticulocytosis) indicate blood loss
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    What is A? What will it turn into?And how long before it reaches the next stage?
    A: Reticulocytes(1 more day for maturation to RBCs)
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    What is this a photo of?
    Mature erythrocytes and a few platelets
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    A. Fimbrae of a Polychromatic eurythrocyte. You can see endosomes & mitochondria inside.
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    • A. Eurythroblast
    • C. Mature Erythrocyte
    • Hint: exact same size except Eyrythroblast still has nucleus.
  16. RBC formation is controlled by what glycoprotein hormone? Where is it made and under what condition?
    Image UploadERYTHROPOIETIN    -  synthesized and secreted by kidney    -  responds to ↓ levels of O2 in the blood.
  17. How long does it take RBC to get old? What happens to it?
    120 days. Macrophage system of spleen, liver and  bone marrow   -  phagocytose and degrade      senescent (old) RBCs
  18. How does Hemoglobin breakdown?
    • Hemoglobin =heme + globin.
    • Globin amino acids are reused.
    • Heme releases Fe, which converts into hemosiderin or ferritin stored in SPLEEN for Hb synthesis
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    A:2 Large in the middle are Megakaryocyte with platelet demarcation channels making platelets.B. Immature  WBC and RBC (Hematopeitic cells)C.AdiposeD.Spongy bone (streams of bone)E.Osteocyte cells
Author:
sabamed
ID:
236026
Card Set:
histology of blood part I A
Updated:
2013-09-20 23:28:52
Tags:
block II saba sabamed hematopoiesis hemopoeisis
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histology block II
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