Aspirin, Ibuprofen, Diclofenac, Naproxen,
- Anti-inflammatory action due to decrease in PGE2
- and prostacyclin production causing reduced vasodilation and oedema. Analgesic
- effect due to decreased prostaglandin production and thus less sensitization of
- nociceptive nerve endings to inflammatory mediators such as bradykinin.
- Antipyretic actions as NSAIDs prevent IL-1 activating COXs in the CNS, which
- produce prostaglandins that raise the hypothalamic set point.
- Half Life; 1-6 hours (naproxen
- 14 hours)
ADVERSE DRUG REACTIONS
- Gastrointestinal bleeding (due
- to inhibition of COX1 which normally provides prostaglandins to maintain the
- mucosal lining of the stomach N.B
- Ibuprofen is gentlest on the stomach and Misoprostol is a stable analogue of
- PGE1 and can as such be used with NSAIDs to protect against GI bleeding)
- (ASPIRIN) Children <12 (due
- to risk of Reye’s syndrome)
- Beware ‘triple whammy’ drug
- combination of NSAID+ ACEI/ARB+ Diuretic, which can cause acute renal failure.
- Used with caution in IBD