Guaifenesin, Ammonium salts, Senega, Liquoirce
- Dry cough- Opioid Derivatives
- Productive Cough- Expectorants,
- Demulcents, Mucolytics
- Opioid derivatives: activate
- neuronal G-protein coupled opioid receptors, inhibiting adenylate cyclase,
- reducing cAMP levels and activating potassium channels resulting in
- hyperpolarization of the neuron. This reduces the release of substance P, which
- is a neurokinin binding NK-1 which activates the cough centre in the medulla.
- This results in a reduction in the frequency of dry, irritating cough.
- Expectorants: are thought to
- promote bronchial secretions, ciliary action and productive coughing by
- irritant action on mucous membranes. This increases mucous production and
- Demulcents though to suppress
- coughs by forming a protective layer over sensory receptors in the pharynx. This
- suppresses coughing.
- Mucolytics: acetylcysteine:
- reduces mucous viscosity by splitting disulfide bonds in mucoproteins:
- Brohexine: is thought to improve mucous flow by enhancing hydrolyzing activity
- of lysosomal enzymes This results in a reduction of mucous viscosity and aids
- in expectoration
ADVERSE DRUG INTERACTIONS