Histo-Extracellular Matrix

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Author:
latieungao
ID:
236084
Filename:
Histo-Extracellular Matrix
Updated:
2013-09-21 09:58:06
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extracellular matrix
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Description:
about the extracellular matrix
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  1. What is the proteoglycan when the GAG is chondroitin sulfate?
    What is its function?
    • versican
    • for cell-cell, cell-matrix interaction
  2. What is the proteoglycan when the GAG is chondroitin sulfate and keratan sulfate?
    What is its function?
    • aggrecan
    • hydration of the ECM cartilage
  3. What is the proteoglycan when the GAG is dermatan sulfate?
    What is its function?
    • decorin
    • collagen fibrogenesis, fiber orientation, regulates thickness of fibrils and interact with TFG-beta
  4. What is the proteoglycan when the GAG is heparan sulfate?
    What is its function?
    • syndecan
    • cell-EMC interaction
  5. What GAG makes up the proteoglycan versican?
    What is the function of versican?
    • chondroitin sulfate
    • cell-cell, cell-matrix interation
  6. What GAG make the proteoglycan aggrecan?
    What is its function?
    • chondroitin sulfate and keratan sulfate
    • hydration of ECM of cartilage
  7. What GAG make the proteoglycan decorin?
    What is its function?
    • derman sulfate
    • collagen fibrogenesis, fiber orientation, regulates thickness of fibril and interact with TFG-beta
  8. What is the GAG that made syndecan?
    What is syndecan's function?
    • heparan sulfate
    • cell-EMC interaction
  9. What GAG is predominant in cartilage and synovial fluid?
    hyaluronic acid
  10. In what tissue is hyaluronic acid abundant?
    cartilage and synovial fluid
  11. In what tissue is chondroitin sulfate abundant?
    bone and cartilage
  12. What GAG is abundant in bone and cartilage?
    chondroitin sulfate
  13. In what tissue is dermatan sulfate abundant?
    skin and heart valves
  14. What GAG is abundant in skin and heart valves?
    dermatan sulfate
  15. What GAG is abundant in lung and skin?
    herparan
  16. The GAG heparin is abundant in what tissue?
    lung and skin
  17. The GAG heparan sulfate is abundant in what tissue?
    basal laminae
  18. What GAG is abundant in the basal laminae?
    heparan sulfate
  19. What GAG is abundant in carnea, cartilage, interveterbral disc?
    keratan sulfate
  20. In what tissue is the GAG keratan sulfate abundant?
    cornea, cartilage, intervetebral disc
  21. is a matrix adhesive
    glycoprotein, mediates cell-cell adhesion. Has many binding sites. Either
    cell-surface fibronectin or plasma fibronectin- fibrin (blood clotting protein)
    heparin (anti-clotting protein). Promotes healing by binding with fibril. Guide
    immune cells to area.
    fibronectin
  22. is secreted
    by epithelial cells into the adjacent basal laminae.  And external of muscle cells and Schwann
    cells.  binds cell surface
    receptor, collagen IV, heparan sulfate, and entactin. It anchors the epithelia
    cells to the basal lamina. Necessary for cell migration during embryotic
    development. Mutation in (------)5 gene gives rise to epidermolysis bullosa
    (blister).
    laminin
  23. is part of the basement membrane, it links
    laminin with collagen IV in the lamina densa.
    entactin
  24. plays a role in cell-matrix migration; it can promote or discourage cell adhesion cell-dependently.

    It is secretd by glial cells in the developing nervous system and is abundant in embryonic
    tissues.
    tanascin
  25. Plays a role in development and maintenance of cartilage. It attaches collagen type II fibers to chondrocytes. It provides bindings to proteoglycans, collagens, and cell-surface receptors.
    chondronectin
  26. They bind minerals to type I collagen in bones. They influence calcification by influencing crystal growth.
    osteonectin
  27. Is a family of transmembrane glycoproteins that binds to collagen, fibronectin, laminin, and ECM components. They act as cell surface receptors, that binds to extracellular ligans, which have RGD (arginin-glycine-aspartae sequence).
    integrin
  28. What collagen is found in bone, dentin, tendon, dermis, scars, and organ capsules?
    type 1 collagen
  29. Type 1 collagen is found in what tissue?
    bone, dentin, tendon, dermis, scars, organ capsules
  30. what collagen is found in hyaline and elastic cartilage, and vitreous in eye?
    type 2 collagen
  31. type 2 collagen is found in what tissue?
    hyaline and elastic cartilage, vitreous in eye
  32. what collagen is found in reticular fibers?
    type 3 collagen
  33. type 3 collagen is found in what tissue?
    reticular fibers
  34. what collagen is found in the basal laminae and lens of the eye?
    type 4 collagen
  35. where is type 4 collagen found?
    basal laminae and lens of eye
  36. what collagen is found in fetal membranes and small vessels?
    type 5 collagen
  37. where is type 5 collagen found?
    fetal membrane and small vessels
  38. the enzyme collagenases degrades what collagen?
    type 1,2,3,10 collagens
  39. type 1,2,3,10 collagens are degraded by what enzyme?
    collagenase
  40. the enzyme matrilysin degrades what collagen?
    type 4 collagen
  41. type 4 collagen is degraded by what enzyme?
    matrilysins
  42. the enzyme gelatinase degrades what collagen?
    denatured collagen, laminin, firbonectin, elastin
  43. denatured collagen, laminin, fibronectin, elastin are degraded by what enzyme?
    gelatinase
  44. the enzyme stomelysin degrades what collagen?
    denatured collagen, proteoglycan, fibronectin
  45. denatured collagen, proteoglycans, fibronectin are degraded by what enzyme?
    stomelysin
  46. What is osteogenesis imperfecta?
    it is a genetic disorder caused by a type 1 collagen defect. It leads to fragile bones, which are prone for repeated fractures, teeth abnormalities, lax joint, and hearing loss
  47. this genetic disorder is caused by type 1 collagen defect. It leads to fragile bones, which are prone for repeated fractures, teeth abnormalities, lax joints, and hearing loss.
    osteogenesis imperfecta
  48. what is Ehlers Danlos syndrome?
    it is a disease caused by type 3 collagen defect. symtoms include spontaneous arterial, intestinal, urinal rupture, hyperextensible and fragile skin, poor wound healing, easy bruising, pseudotumors, and joint hypermobility.
  49. it is a disease caused by type 3 collagen defect. symtoms include spontaneous arterial, intestinal, urinal rupture, hyperextensible and fragile skin, poor wound healing, easy bruising, pseudotumors, and joint hypermobility.
    Ehlers Danlos syndrome
  50. what is Marfan syndrome
    it is an autosomal dominant disorder caused by defects in the fibrillin-1 gene for glycoproteins that forms microfibrils. symtoms includ dissection at the base of aorta/ aortic aneurysm, long thin extremities, dislocation of lenses (ectopis lentis)
  51. it is an autosomal dominant disorder caused by defects in the fibrillin-1 gene for glycoproteins that forms microfibrils. symtoms includ dissection at the base of aorta/ aortic aneurysm, long thin extremities, dislocation of lenses (ectopis lentis)
    Marfan syndrom

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