Sulfonylureas

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Author:
jcu1
ID:
236085
Filename:
Sulfonylureas
Updated:
2013-09-24 20:05:49
Tags:
Endo
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Description:
Dr. Drab
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  1. Sulfonylureas MOA
    stimulate insulin release from beta cells on pancreas

    binds receptor closing K channel --> depolarizes cell membrane and opens Ca channel --> Ca in, insulin out
  2. first generation sulfs
    • tolbutamide
    • acetohexamide
    • tolazamide
    • chlorpropamide
  3. 1st gen sulf that has a very long half life
    chlorpropamide - 35h
  4. Metabolism and elimination of sulfonylureas
    Metabolized in liver; renally excreted
  5. second gen sulfs
    • glyburide
    • glyburide micronized
    • glipizide
    • glimepiride
  6. hypoglycemic action made worse by:
    quinolones (worse)

    • NSAIDs
    • beta blockers
    • fluoxtine
  7. sulfonylureas contraindications
    • type 1 DM
    • diabetic ketoacidosis
  8. Sulfonyureas side effects
    • hypoglycemia (big one)
    • weight gain
    • hematologic (leukopenia, thrombocytopenia, anemia)
    • dermatological (rash, puritis, purpura)
    • GI (N/V, cholestasis)
  9. chlorpropamide specific side effects
    • disulfiram-like rxn
    • hyponatremia
    • cholestatic jaundice

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