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a. associated with membrane by __
b. can be solubilized by __ that __holding peripheral proteins to a membrane
- weak electrostatic bonds
- extraction with high-concentration salt solutions
- weaken the electrostatic bonds
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c. best studied peripheral proteins are located on the __ of the plasma membrane, where they form a __ that acts as a __
i. these proteins provide __ for the membrane and function as an __for __membrane proteins
- internal (cytosolic)
- fibrillar network
- membrane "skeleton"
- mechanical support
- anchor
- integral
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b. other peripheral proteins on the internal plasma membrane surface function as __, __, or __ that transmit transmembrane signals
c. have dynamic relationship with the membrane, being recruited to __ the membrane
- enzymes, specialized coats, or factors
- recruited to or replaced from
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a. numerous proteins on the external membrane are bound by small, complex __linked to a molecule __embedded in the __ of the lipid bilayer
i. __membrane proteins containing this type of __ are __ proteins
- oligosaccharides
- PI
- outer leaflet
- peripheral
- glycosyl-phosphatidylinositol linkage
- GPI-anchored
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a. On the cytoplasmic side, proteins are anchored to the membrane by one or more __ embedded in the __ of the lipid bilayer
i. ex: Src and Ras can transform cell to malignant one
- long hydrocarbon chains
- inner leaflet
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