Card Set Information
Stimulates beta cells to produce more insulin
How to take Sulfonylurea
with or without food
Increase sensitivity of liver and muscle to insulin; Decrease hepatic glucose production; improve transport into cells
lactic acidosis; not weight gain
Use of contrast media; must have normal renal function
a-glucosidase inhibitor actions
Delay digestion of carbohydrates, causing glucose to enter blood more slowly
a-glucosidase inhibitors are also called
a-glucosidase inhibitor s/e
Excess gas; does NOT cause hypoglycemia
What 3 defences of Type 2 DM do oral drug therapy agents work on?
Insulin resistance, decreased insulin production, increased hepatic glucose production
increase insulin production
When to take Meglitinide
Up to 30 minutes before meal; do not take if meal is skipped
Improve insulin sensitivity, transport, and utilization at target tissues
Linked to MIs
Dipeptidyl peptidase-4 (DDP-4) inhibitor action
Slows the inactivation of incretin hormones
hypoglycemia; not weight gain
Amylin analog action
Slows gastric emptying, reduces postprandial glucagon secretion, increases satiety
What is amylin?
hormone secreted by b-cells (co-secreted w/insulin)
How is amylin analog administered?
SQ, but not in arm
Incretin mimetic action
Stimulates release of insulin from b-cells; Suppresses glucagon secretion; Reduces food intake; Slows gastric emptying
What is Incretin mimetic
How is Incretin mimetic administered?
Incretin mimetic s/e