SGLT-2 inhibitors

Card Set Information

Author:
jcu1
ID:
236200
Filename:
SGLT-2 inhibitors
Updated:
2013-09-24 20:09:27
Tags:
Endo
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Description:
Dr. Drab
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  1. unique part about SGLT2 inhibitors
    • no dependent on beta cell function or insulin resistance
    • less glucose in blood also decreases amt that the pancreas has to work
  2. SGLT-2 inhibitor MOA
    • inhibitor of SGLT2
    • blocks reabsorption of filtered glucose and reduce renal threshold for glucose
  3. SGLT-2 inhibitor drug
    canagliflozin
  4. SGLT-2 inhibitors CI
    • hypersensitivity
    • severe renal impairment (GFR < 30 ml/min; ESRD; on dialysis)
  5. SGLT-2 inhibitors precautions
    • hypotension (watch out for hypovolemia in pts with renal impairment, elderly, low systolic bp, or on diuretics, ACEi or ARB)
    • impaired renal fx
    • hyperkalemia
    • hypoglycemia with other meds that cause hypoglycemia
    • genital mycotic infections
    • inc LDL
  6. SGLT-2 inhibitors DDIs
    • digoxin - inc AUC and Cmax
    • inducers of UGT 1A9 and UGT2BB (rifampin, ritonavir, phenobarbital, phenytoin)

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