Immunosuppressants

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Author:
andresjm
ID:
23660
Filename:
Immunosuppressants
Updated:
2010-06-15 12:07:19
Tags:
Step USMLE immunosuppressants
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Description:
Step 1 USMLE immunosuppressants
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  1. Cyclosporine: MOA
    Inhibits calcineurin to prevent IL-2 production (and therefore T cell activation)
  2. Cyclosporine: toxicity
    • Viral infections, lymphoma
    • Nephrotoxic (prevent with mannitol)
  3. Tacrolimus (FK506): MOA
    • Similar to cyclosporine
    • Binds to FK-binding protein inhibiting secretion of IL-2 and others
  4. Tacrolimmus: toxicity
    • Nephro, neuro
    • HTN, pleural effusion, hyperglycemia
  5. Azathioprine/6-MP: MOA
    Interferes with nucleic acid synthesis
  6. Azathioprine/6-MP: tox
    • active metabolite mercaptopurine is metabolized by XO
    • BM suppression
  7. Muromonab-CD3 (OKT3)
    Ab binding CD3 on T cell surface
  8. Sirolimus/rapamycin: MOA
    Binds mTOR to inhibit T cell prolif in reseponse to IL2
  9. Sirolimus/rapamycin: tox
    HLD, thrombocytopenia, leukopenia
  10. MMF: MAO
    Inhibits de novo guanine syntehsis
  11. Daclizumab: MOA
    Ab for IL-2 receptor on activated T cells
  12. Aldesleukin
    IL-2 for RCC and melanoma
  13. Filgrastim
    G-CSM for BM recovery
  14. Sargramostim
    GM-CSF for BM recovery
  15. a-IFN uses
    HBV, HCV, Kaposi's, leukemias, melanoma
  16. B-IFN use
    MS
  17. g-IFN use
    CGD
  18. Drugs for thrombocytopenia
    • Oprelvekin (IL-11)
    • Thrombopoietin

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