Diabetes Drug MOAs

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Author:
jcu1
ID:
236785
Filename:
Diabetes Drug MOAs
Updated:
2013-09-24 15:20:03
Tags:
Endo
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Description:
Dr. Drab
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  1. Sulfonylureas
    • stimulate insulin release from beta cells
    • bind to ATP-dependent potassium channel --> depolarizes membran --> Ca in , inuslin out

    fasting
  2. meglitinides
    • stimulate insulin release from beta cells
    • mimic the normal physiologica response seen in non diabetics

    post-prandial
  3. alpha-glucosidase inhibitors
    • inhibit intestinal amylase and alpha-glucosidase
    • delay of complex carb breakdown
    • glucose absorption delayed to distal portion of small intestine

    post-prandial
  4. Biguanides
    • 1: decrease hepatic glucose production
    • 2: improve insulin sensitivity; decrease intestinal absorption of glucose

    fasting
  5. Thiazolidinediones
    1: stimulation of PPAR-gamma --> increase in GLUT-4 on cell surface --> inc in insulin dependent glucose uptake in muscle and adipose

    2: decrease in hepatic glucose production

    Fasting
  6. GLP-1 agonist
    • stimulates insulin response from beta cells (glucose dependent)
    • inhibits gastric emptying
    • inhibits glucagon secretion from alpha cells (glucose dependent)

    post-prandial
  7. DPP-4 Inhibitors
    • inhibits DPP-4 enzyme --> prolongs incretin levels
    • increases insulin release and decreases glucagon secretion (glucose dependent)
  8. SGLT-2 inhibitors
    • block SGLT-2
    • less reabsorption of glucose (renal glucose threshold reduced) --> inc urinary gluc excretion

    fasting
  9. bile acid sequestrants
    • binds bile acids in intestine --> more cholesterol turned into bile acids
    • for DM: not understood
  10. Bromocriptine
    • dopamine d2 receptor agonist
    • decreases HGP, adipose lipolysis, insulin resistance

    fasting
  11. liraglutide
    • GLP-1 analog
    • stimulates insulin secretion with elevated glucose
    • suppresses glucagon secretion (glucose dependent)
    • delays gastric emptying

    post-prandial
  12. amylinmimetic/neuroendocrine hormone

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