USMLE psych pharm

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Author:
andresjm
ID:
23679
Filename:
USMLE psych pharm
Updated:
2010-06-15 16:08:58
Tags:
USMLE psychiatry pharmacology
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Description:
USMLE psychiatry pharmacology
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  1. Name the typical antipsychotics
    • haloperidol plus the -azines
    • e.g. trifluoperazine, fluphenazine, thioridazine, chlorpromazine
  2. Antipsychotics: MOA
    block DA D2 receptors to increase cAMP
  3. Name the atypical antipsychotics
    Olanzaine, clozapine, quetiapine, risperidone, aripiprazole, ziprasidone
  4. Lithium: tox
    • tremor sedation edema heart block
    • hypothyroidism
    • polyuria (NDI)
    • Ebstein's anomaly (atrialized right ventricle)
  5. Buspirone: use and MOA
    • GAD
    • Stimulates 5-HT1A receptors
  6. name the TCAs
    • imipramine, desipramine, clomipramine
    • amitriptyline, nortriptyline
    • doxepin, amoxapine
  7. TCAs: MOA
    block NE and 5HT reuptake
  8. TCAs: tox and tx
    • Convulsions Coma Cardiotox
    • treat with NaHCO3 for CV tox
  9. SSRIs: name them
    • fluoxetine
    • paroxetine
    • sertraline
    • citalopram
  10. SNRIs: name them
    • venlafaxine (GAD)
    • duloxetine (neuropathy, greater NE effect)
  11. MAOis: name them
    • phenelzine
    • selegiline (B only)
    • tranylcypromine
    • isocarboxazid
  12. Buproprion: MOA
    increase NE and dopamine via unknown mechanism
  13. Mirtazapine: MOA
    • alpha2 antagonist increases NE and serotonin release
    • 5HT2 and 3 receptor antagonist
    • for depression
  14. Maprotiline: MOA
    • blocks NE reuptake
    • for depression
  15. Trazodone: MOA
    • inhibits serotonin reuptake
    • used for insomnia
    • high doses needed for depression

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