3220 inflammatory

Card Set Information

Author:
jam110007
ID:
236931
Filename:
3220 inflammatory
Updated:
2013-09-24 23:38:38
Tags:
3220 inflammatory
Folders:

Description:
3220 inflammatory
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user jam110007 on FreezingBlue Flashcards. What would you like to do?


  1. The 5 LOCAL Manifestations (signs) of inflammation
    - Rubor = redness, from hyperemia [sudden surge of blood circulating to that area]

    • - Calor = heat, from increased metabolism and activity at the site casuing it
    • to heat up

    • - Dolor = pain, from change in pH, nerve stimulation by chemicals like histamine,
    • pressure from swelling 

    • - Tumor = swelling, from fluid exudates, leaking capillaries [due to a release of
    • histamine which thins out the walls of the capillary thus resulting in leaking
    • capillaries]

    - Functio laesa = loss of function, from the swelling and pain [fluid leaking out is called an exudate. The exudate that leaks out causes the swelling]
  2. Inflammatory Response
    • - Sequence of automatic, normal
    • physiological events in vascularized tissues

    - Neutralizes harmful agents [the extra fluid will dilute the toxin and prevent the toxin from damaging and circulating into the body by localizing it to one spot]

    - Rids body of foreign agents/dead tissue

    - Prepares for phase of wound healing
  3. Common CAUSES of Inflammation
    • - Infection
    • - Burns
    • - Chemicals
    • - Surgery
    • - Extremes of hot or cold
    • - Immune reactions
    • - Ischemic damage
  4. What starts it – and what can stop inflammation
    • - Damaged cell membranes release inflammatory mediators like arachidonic
    • acid – corticosteriods can block this

    - Arachidonic acid stimulates 2 pathways, LIPOXYGENASE & CYCLOOXYGENASE making leukotrienes & prostaglandins & thromboxane

    - NSAIDS & aspirin stop cyclooxygenase path, decreasing prostaglandins
  5. 2 types of Inflammation
    • - Acute (should happen, a good thing)
    • - Chronic (shouldn’t happen, a bad thing)
  6. Acute inflammation
    WBC involved is mostly neutrophils, exudates are present
  7. chronic inflammation
    WBC types are lymphocytes & macrophages [much later in the inflammatory process]
  8. ACUTE Inflammation has 2 Phases
    1. Vascular (blood vessel) Phase [really really fast] - Hemodynamic changes

    • 2. Cellular Phase - Actions of certain WBCs (White Blood Cells) begin to clean up damage and the mediators
    • the are present 

    • Then a whole body response
    • occurs with WBCs and “acute phase response”
    • - Early signs fever and lethargy
  9. Acute Inflammation – phase 1 Vascular Phase
    • 1.Vasoconstriction response – stops bleeding
    • - 5-10 minutes
    • - Decreased blood flow

    • 2.Hyperemic response [when
    • it turns red] – brings rescue materials (prostaglandins & leukotrienes):
    • - Increased blood flow
    • - Increased capillary permeability, leaking
    • - Causes “EXUDATES”
  10. Acute Inflammation, Phase 2:  the Cellular Response
    - Delivery of WBC (mainly NEUTROPHILS) to the injury site

    - Activation of the neutrophils by chemicals in the area

    - Phagocytosis – clean up [enclose, neutralize and gets rid of toxins]
  11. The CELLULAR Response - which WBC play a role?
    • - granulocytes
    • - eosinophils
    • - basophils
  12. granulocytes
    • neutrophils
    • - move in within 90 min 
    • - polymorph

What would you like to do?

Home > Flashcards > Print Preview