Card Set Information
What are the 4 types of hypersensitivity?
: mediated disease
: immune complex-mediated disease
: T-cell mediated diseases
Type I may be caused by what/be what?
protein allergens binding to IgE
What are the steps of Type I hypersensitivity?
protein allergy bind to IgE
IgE activates mast cells
IgE binds receptors present/absence of Ag
IgE binds Fc receptor
What Fc receptors do IgE bind to?
What are the physical effects of mast cell degranulation?
gastrointestinal, airways, blood vessels
What gastrointestinal effect?
increased fluid secretion, increased peristalsis=diarrhea/vomiting
What blood vessel physical effect?
^ blood flow, ^ permeability=edema, inflammation
occurs within minutes
What does systemic release?
histamine, serotonin, leukotrienes
What are the physical effects of systemic?
labored resp, hypotension, edema
contraction of GI tract/bladder
bronchiole constr=death by asphyxiation
What is anaphlyaxis due to?
insect stings, foods, medicines such as penicillin
What med would you give for anaphylaxis?
stimulates tight junction=relaxes constricted smooth muscle
What are local type I hypersensitivity?
asthma, food allergies
How is Type I localized characterized?
chronic airway inflammatory/hyperreactivity
leads to airway obstruction