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What are the 4 types of hypersensitivity?
- TI: immediate-type
- TII: mediated disease
- TIII: immune complex-mediated disease
- TIV: T-cell mediated diseases
Type I may be caused by what/be what?
- protein allergens binding to IgE
What are the steps of Type I hypersensitivity?
- protein allergy bind to IgE
- IgE activates mast cells
- IgE binds receptors present/absence of Ag
- IgE binds Fc receptor
What Fc receptors do IgE bind to?
- mast cells
- activated eosinophils
What are the physical effects of mast cell degranulation?
gastrointestinal, airways, blood vessels
What gastrointestinal effect?
increased fluid secretion, increased peristalsis=diarrhea/vomiting
What blood vessel physical effect?
^ blood flow, ^ permeability=edema, inflammation
occurs within minutes
What does systemic release?
histamine, serotonin, leukotrienes
What are the physical effects of systemic?
- labored resp, hypotension, edema
- contraction of GI tract/bladder
- bronchiole constr=death by asphyxiation
What is anaphlyaxis due to?
insect stings, foods, medicines such as penicillin
What med would you give for anaphylaxis?
stimulates tight junction=relaxes constricted smooth muscle
What are local type I hypersensitivity?
asthma, food allergies
How is Type I localized characterized?
- chronic airway inflammatory/hyperreactivity
- leads to airway obstruction
What would you like to do?
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