MMHypersensitivity

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Author:
maria_mm_10
ID:
237093
Filename:
MMHypersensitivity
Updated:
2013-09-25 21:12:44
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Exam 1
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  1. What are the 4 types of hypersensitivity?
    • TI: immediate-type
    • TII: mediated disease 
    • TIII: immune complex-mediated disease
    • TIV: T-cell mediated diseases
  2. Type I may be caused by what/be what?
    • systemic/localized
    • protein allergens binding to IgE
  3. What are the steps of Type I hypersensitivity?
    • protein allergy bind to IgE
    • IgE activates mast cells 
    • IgE binds receptors present/absence of Ag
    • IgE binds Fc receptor
  4. What Fc receptors do IgE bind to?
    • mast cells
    • basophils
    • activated eosinophils
  5. What are the physical effects of mast cell degranulation?
    gastrointestinal, airways, blood vessels
  6. What gastrointestinal effect?
    increased fluid secretion, increased peristalsis=diarrhea/vomiting
  7. What blood vessel physical effect?
    ^ blood flow, ^ permeability=edema, inflammation
  8. Systemic anaphlaxis
    occurs within minutes
  9. What does systemic release?
    histamine, serotonin, leukotrienes
  10. What are the physical effects of systemic?
    • labored resp, hypotension, edema
    • contraction of GI tract/bladder 
    • bronchiole constr=death by asphyxiation
  11. What is anaphlyaxis due to?
    insect stings, foods, medicines such as penicillin
  12. What med would you give for anaphylaxis?
    stimulates tight junction=relaxes constricted smooth muscle
  13. What are local type I hypersensitivity?
    asthma, food allergies
  14. How is Type I localized characterized?
    • chronic airway inflammatory/hyperreactivity 
    • leads to airway obstruction

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