Bone formation Histo Lect 1 part 1
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Two types of bones. what are they and what are some distinguishing characteristics?
- 1. Compact Dense bones- no bone marrow, butblood vessels CAN be seen, outside region of bone
- 2. Spongy bone aka Cancellous- bone marrow, blood vessels exist, inner region of bone
What is arrow? Black spaces? Orange lines? Purple spaces?
- White: compact dense bone
- Black space: Cancellous bone with bone marrow cavity. Orange: compact dense. Purple: cancellous and bone marrow cavity.
What is this?
Epiphysis of long bone- adult
- A. Epiphysis
- B. Metaphysis
- C. Diaphysis
- D. Compact Bone
- E. Articular surface (no periosteum here)
- F. Cancellous/spongy bone
- B. Hemopoetic elements (Fat, etc.)
- A:Osteocyte filling lacuna
- A. Haverson Canal
- B. Blood vessel
- C. Compact bone
- A. Osteoblast building bone appositionally
- B. Osteoclast (multinucleated cells) resorbing bone
- C. Bone
- SM, Skeletal muscle; P, periosteum; Os, osteon (haversian
- system); M, bone marrow.Outer covered by periosteum (sheath of dense connective tissue)
Sharpey's fibers (pink) where ligament and tendons attach (white). •Where ligaments and tendons attach: NO PERIOSTEUM!•collagen fibers of the tendon extend directly at an angle into bone tissue •where they are continuous with bone collagen fibers
ENDOSTEUM! •layer of connective tissue cells with OSTEOPROGENITOR cells•Found in:•long bones•and trabeculae of spongy bone•Often one cell-thick layer of flattened cells •look like fibroblasts •can differentiate into osteoblasts •called ENDOSTEAL CELLS
Ephysis on left. Inside- white cavity with bone marrow lined by endosteum cells. A Hyaline CartilageB. BoneC. PeriosteumD. EndosteumE. Medullary Cavity with Bone matrixF. Endosteum (close up; one cell thick)
- Mature compact bone with layers (top to bottom)
- 1. Inner circumferential Lamelle
- 2. Osteons aka Haverson Systems •cylindrical units of compact bone•consist of concentric lamellae of matrix around a central canal•the osteonal canal or HAVERSIAN CANAL•Canal contains vascular and nerve supply of the osteon•lined with endosteal/osteoprogenitor cells
- 3. Outer circumferential lamelle
- . A: Haverson System concentric layers around B. blood vessels
- and loose CT with osteogenic cells, erpiceytes, etc. dark spots are lacunae where osteocytes found. Arrows: cannaliculi surround the haverson systems.
What is this a photo of?
Haverson Systems (collection of haverson canals)
- HS: Haverson Canal
- OPC: Osteopericyte
- OC: Osteoclasts
What is this a photo of? What is in the center of the circle? Why are there gradients in color?
Section of a haversian system, or osteon. Note the alternation of clear and dark circles resulting from the alternation in the direction of the collagen fibers (head to toe formation). The type I collagen fibers appear bright when cut longitudinally and dark when cross-sectioned. Inthe center of the osteon is a channel. PSP stain.
What is this a photo of?
Deminieralized bone. Haverson System comprised of haverson canals.
What are these canals connecting lacunae called? What is radial looking in this photo? What kind of canal is in the photo and what's the purpose?
•CANALICULI•Canals connecting the lacunae •In living bones occupied with osteocyte processes•arranged radially with respect to Haversian canal•canaliculi system opens into Haversian canal•serves for passage of substances between osteocytes and blood vessels
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